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[(mean)-264.6(DBP:)]TJ /F17 1 Tf 4.8338 0 TD ()Tj /F12 1 Tf 0.5729 0 TD [(3.27)-260.6()-263.5(5.33,)-269.4(P)-261.5(<)-264.6(0.001\))-268.1(\()]TJ /F21 1 Tf 0 0 0 rg 9.6139 0 TD [(Figure)-265.9(1A)]TJ /F12 1 Tf 0 0 0 1 k 4.1654 0 TD [(\).)-268.5(However,)-266.9(a)]TJ -20.3199 -1.2114 TD [(medium-term)-361.8(blood)-355.8(pressure-lowering)-359.4(ef)56.5(fect)-353.4(of)-354.8(WMT)-361.7(was)-354.1(not)]TJ 0 -1.2055 TD [(found.)-375.9(There)-368.3(was)-372(no)-373.3(signi)]TJ /F14 1 Tf 10.8253 0 TD ()Tj /F12 1 Tf 0.5311 0 TD [(cant)-368.8(dif)62.5(ference)-374.5(in)-374.6(blood)-367.7(pressure)-377.9(1)]TJ -11.3564 -1.2114 TD [(month)-250.1(after)-248.9(the)]TJ /F14 1 Tf 6.4928 0 TD ()Tj /F12 1 Tf 0.5311 0 TD [(rst)-253(WMT)-248.3(\(before)-249.3(the)-254.9(second)-250.7(WMT\))-251.4(compared)]TJ -7.0239 -1.2114 TD [(with)-217.2(that)-218.3(before)-216.4(the)]TJ /F14 1 Tf 7.9489 0 TD ()Tj /F12 1 Tf 0.5311 0 TD [(rst)-217.2(WMT)-212.5(\()]TJ /F18 1 Tf 4.2728 0 TD ()Tj /F12 1 Tf 1.1339 0 TD (SBP:)Tj /F17 1 Tf 2.0529 0 TD ()Tj /F12 1 Tf 0.5729 0 TD [(2.23)-212.9()-215.7(17.54,)-220.1(P)-213.8(=)-221.7(0.280;)]TJ /F18 1 Tf -16.5125 -1.2114 TD ()Tj /F12 1 Tf 1.1339 0 TD (DBP:)Tj /F17 1 Tf 2.3393 0 TD ()Tj /F12 1 Tf 0.5729 0 TD [(1.00)-242.7(\()]TJ /F17 1 Tf 2.2379 0 TD ()Tj /F12 1 Tf 0.5729 0 TD [(10.00)-247.1(to)-242.3(3.00\),)-242.7(P)-243.6(=)-239.6(0.052;)]TJ /F18 1 Tf 10.0973 0 TD ()Tj /F12 1 Tf 1.1398 0 TD [(mean)-240.7(SBP:)]TJ /F17 1 Tf 4.5235 0 TD ()Tj /F12 1 Tf 0.5729 0 TD [(1.26)-242.7()]TJ -23.1903 -1.2114 TD 0.022 Tc [(8.75,)-517.9(P)-520(=)-522(0.31)5.7(8;)]TJ /F18 1 Tf 7.7221 0 TD 0 Tc ()Tj /F12 1 Tf 1.1518 0 TD 0.022 Tc [(mean)-523.1(D)5(B)-3.7(P)5.1(:)]TJ /F17 1 Tf 5.5141 0 TD 0 Tc ()Tj /F12 1 Tf 0.5908 0 TD 0.022 Tc [(0.22)-519.5()-522(7)-0.3(.50,)-517.9(P)-520(=)-522(0.83)5.7(8\))]TJ -14.9788 -1.2114 TD 0 Tc (\()Tj /F21 1 Tf 0 0 0 rg 0.3461 0 TD [(Figure)-474.8(1A)]TJ /F12 1 Tf 0 0 0 1 k 4.3803 0 TD [(\).)-477.4(With)-481.2(regard)-484.5(to)-475.1(the)-475.7(second)-483.4(WMT,)-477.9(there)-483.4(was)-479.4(a)]TJ -4.7264 -1.2055 TD (signi)Tj /F14 1 Tf 1.8858 0 TD ()Tj /F12 1 Tf 0.5311 0 TD [(cant)-255.4(decrease)-255.5(in)-255.3(SBP)-254.9(at)-251.6(hospital)-255.5(discharge)-262.2(after)-254.8(the)-254.9(second)]TJ -2.4169 -1.2114 TD [(WMT)-290.1(compared)-293.8(with)-288.8(that)-283.9(at)-287.4(hospital)-291.3(admission)-292.4(before)-293.9(the)]TJ /F14 1 Tf 24.0974 0 TD ()Tj /F12 1 Tf 0.5311 0 TD (rst)Tj -24.6285 -1.2114 TD [(WMT)-510.9(\()]TJ /F18 1 Tf 3.324 0 TD ()Tj /F12 1 Tf 1.1339 0 TD [(SBP)-10.2(:)]TJ /F17 1 Tf 2.3453 0 TD ()Tj /F12 1 Tf 0.5789 0 TD [(5.55)-511.3()-502.2(16.7)-10(3,)-508.5(P)-506.2(=)-502.2(0.)-7.2(014)-7.2(\).)-507.2(DBP)-507.1(at)-508.2(hos)-7.4(pita)-8.7(l)]TJ 20.0692 43.7369 TD [(discharge)-494.9(after)-499.5(the)-493.6(second)-495.4(WMT)-493(\()]TJ /F18 1 Tf 14.8714 0 TD ()Tj /F12 1 Tf 1.1339 0 TD (DBP:)Tj /F17 1 Tf 2.584 0 TD ()Tj /F12 1 Tf 0.5729 0 TD [(5.50)-499.3(\()]TJ /F17 1 Tf 2.4945 0 TD ()Tj /F12 1 Tf 0.5729 0 TD [(12.00)-497.7(to)]TJ -22.2295 -1.2114 TD [(1.00\),)-260.6(P)-261.5(=)-257.5(0.069\))-262.2(and)-256.5(mean)-258.6(SBP)-260.8(and)-262.5(mean)-258.6(DBP)-262.4(after)-260.8(the)-254.9(second)]TJ T* [(WMT)-302(\()]TJ /F18 1 Tf 3.1151 0 TD ()Tj /F12 1 Tf 1.1339 0 TD [(mean)-306.4(SBP:)]TJ /F17 1 Tf 4.6428 0 TD ()Tj /F12 1 Tf 0.5729 0 TD [(3.00)-302.4(\()]TJ /F17 1 Tf 2.3035 0 TD ()Tj /F12 1 Tf 0.5729 0 TD [(9.75)-302.4(to)-302(3.00\),)-302.4(P)-303.3(=)-305.2(0.051;)]TJ /F18 1 Tf 9.9779 0 TD ()Tj /F12 1 Tf 1.1339 0 TD (mean)Tj -23.4529 -1.2114 TD (DBP:)Tj /F17 1 Tf 2.3095 0 TD ()Tj /F12 1 Tf 0.5729 0 TD [(1.31)-212.9()-215.7(7.83,)-215.7(P)-213.8(=)-215.7(0.298\))-220.4(were)-215.7(lower)-215.9(than)-218(the)-213.1(corresponding)]TJ -2.8824 -1.2114 TD [(values)-335.9(before)-329.7(the)]TJ /F14 1 Tf 7.1791 0 TD ()Tj /F12 1 Tf 0.5311 0 TD [(rst)-336.6(WMT,)-334.7(although)-332.1(the)-332.4(dif)62.5(ferences)-338.7(were)-335(not)]TJ 9.5 0 0 9.5 306.1417 652.9321 Tm (signi)Tj /F14 1 Tf 1.8858 0 TD ()Tj /F12 1 Tf 0.5311 0 TD [(cant)-303.2(\()]TJ /F21 1 Tf 0 0 0 rg 2.3393 0 TD [(Figure)-301.7(1A)]TJ /F12 1 Tf 0 0 0 1 k 4.2072 0 TD (\).)Tj -7.6983 -1.2055 TD [(In)-415(normotensive)-422.1(patients,)-423.5(although)-415.6(WMT)-421.4(led)-419.3(to)-415.4(a)-416.4(modest)]TJ -1.2651 -1.2114 TD 0.0116 Tc [(bl)5(ood)-506.8(pressure-lowering)-515.1(e)3.9(f)57.9(f)4.2(ect)-509.9(with)-513.7(regard)-512.7(to)]TJ /F18 1 Tf 20.1468 0 TD 0 Tc ()Tj /F12 1 Tf 1.1458 0 TD 0.0094 Tc [(DBP)-514.7(\()]TJ /F14 1 Tf 2.775 0 TD 0 Tc ()Tj /F12 1 Tf 0.5371 0 TD 0.012 Tc (rst)Tj -24.6046 -1.2114 TD 0 Tc (WMT:)Tj /F13 1 Tf 3.1211 0 TD ()Tj /F12 1 Tf 0.5072 0 TD [(3.21)-433.7()-430.6(9.62,)-436.5(P)-428.6(=)-430.6(0.001;)-434.9(second)-435.7(WMT:)]TJ /F17 1 Tf 16.4946 0 TD ()Tj /F12 1 Tf 0.5729 0 TD [(2.51)-427.7()-436.5(8.29,)]TJ -20.6958 -1.2114 TD [(P)-201.9(<)-205(0.001\))-202.5(and)]TJ /F18 1 Tf 5.8901 0 TD ()Tj /F12 1 Tf 1.1398 0 TD [(mean)-204.9(DBP)-202.8(\()]TJ /F14 1 Tf 4.8278 0 TD ()Tj /F12 1 Tf 0.5311 0 TD [(rst)-205.3(WMT:)]TJ /F17 1 Tf 4.1236 0 TD ()Tj /F12 1 Tf 0.5729 0 TD [(2.51)-206.9()-203.8(8.29,)-203.8(P)-201.9(<)-205(0.001;)]TJ -17.0854 -1.2114 TD [(second)-376(WMT:)]TJ /F17 1 Tf 6.1944 0 TD ()Tj /F12 1 Tf 0.5729 0 TD [(2.00)-380(\()]TJ /F17 1 Tf 2.3751 0 TD ()Tj /F12 1 Tf 0.5729 0 TD [(5.40)-380(to)-373.6(2.00\),)-374(P)-374.9(=)-376.9(0.011\),)-378.4(SBP)-374.2(was)-377.9(not)]TJ -9.7153 -1.2114 TD [(af)59.6(fected)-300.6(signi)]TJ /F14 1 Tf 5.2157 0 TD ()Tj /F12 1 Tf 0.5311 0 TD [(cantly)-305.3(by)-295.2(WMT)-302(\()]TJ /F21 1 Tf 0 0 0 rg 7.0776 0 TD [(Figure)-301.7(1B)]TJ /F12 1 Tf 0 0 0 1 k 4.1416 0 TD (\).)Tj /F1 1 Tf 11.9999 0 0 11.9999 306.1417 561.4865 Tm [(Ef)59.9(fect)-302.8(of)-302.4(WMT)-297.9(on)-301.2(Blood)-302.5(Pressure)]TJ 0 -1.0441 TD [(in)-300.9(Hypertensive)-306.3(Patients)-302.3(With)]TJ 0 -1.0394 TD [(Dif)59(ferent)-303.4(Characteristics)]TJ /F12 1 Tf 9.5 0 0 9.5 306.1417 524.9763 Tm [(Next,)-273.9(we)-273.6(analyzed)-272.7(which)-276.4(types)-273.4(of)-271.2(hypertensive)-277.2(patients)-277.5(\(n)-267.8(=)-275.4(73\))]TJ 0 -1.2114 TD [(had)-302.3(a)-297(more)-307(signi)]TJ /F14 1 Tf 6.8091 0 TD ()Tj /F12 1 Tf 0.5311 0 TD [(cant)-297.2(improvement)-310.1(in)-297.1(blood)-302.1(pressure)-306.3(\()]TJ /F18 1 Tf 15.3548 0 TD ()Tj /F12 1 Tf 1.1339 0 TD (SBP,)Tj /F18 1 Tf -23.8289 -1.2114 TD ()Tj /F12 1 Tf 1.1339 0 TD (DBP,)Tj /F18 1 Tf 2.4288 0 TD ()Tj /F12 1 Tf 1.1339 0 TD [(mean)-342.2(SBP,)-335.3(and)]TJ /F18 1 Tf 6.5525 0 TD ()Tj /F12 1 Tf 1.1339 0 TD [(mean)-336.2(DBP\))-337.2(after)-338.4(WMT.)-340.6(Twenty)]TJ -12.3829 -1.2114 TD [(patients)-313.3(and)-310.2(53)-307.1(hypertensive)-313(patients)-313.3(underwent)-310.1(WMT)-314(to)-308(treat)]TJ T* [(an)-460.2(organic)-461.4(disease)-463.5(\(e.g.,)-462.4(in)]TJ /F14 1 Tf 11.255 0 TD ()Tj /F12 1 Tf 0.5311 0 TD [(ammatory)-461.2(bowel)-455.8(disease,)-466.3(chronic)]TJ -11.7861 -1.2055 TD [(liver)-239.2(disease,)-239.5(and)-244.6(gastroesophageal)-240.1(re)]TJ /F14 1 Tf 14.7401 0 TD ()Tj /F12 1 Tf 0.5311 0 TD [(ux)-241.3(disease\))-239.8(and)-238.6(functional)]TJ -15.2712 -1.2114 TD [(diseases)-427.7(\(e.g.,)-432.5(functional)-429.7(bowel)-426(disorder,)-436.6(functional)-429.7(dyspepsia,)]TJ T* [(and)-435.5(gut)-432.7(dysbiosis\),)-444.1(respectively.)]TJ /F21 1 Tf 0 0 0 rg 13.5406 0 TD [(Figure)-433(2A)]TJ /F12 1 Tf 0 0 0 1 k 4.7741 0 TD [(shows)-434.5(that)-433.1(WMT)]TJ -18.3147 -1.2114 TD [(seemed)-356.1(to)-349.8(have)-354.1(a)-350.7(better)-349.7(antihypertensive)-360.4(ef)62.5(fect)-353.4(in)-350.8(hypertensive)]TJ T* [(patients)-301.4(who)-297.1(underwent)-298.1(WMT)-302(to)-296.1(treat)-297.5(organic)-300.3(diseases)-302.4(than)-301.6(in)]TJ T* [(those)-244.2(who)-237.5(underwent)-244.4(WMT)-242.3(to)-242.3(treat)-243.8(functional)-244.7(diseases)-242.7(\()]TJ /F18 1 Tf 22.695 0 TD ()Tj /F12 1 Tf 1.1339 0 TD (SBP:)Tj /F17 1 Tf -23.8289 -1.2114 TD ()Tj /F12 1 Tf 0.5729 0 TD [(11.42)-342.6()-341.1(19.30)]TJ /F15 1 Tf 5.8662 0 TD (vs)Tj /F12 1 Tf 0.7698 0 TD (.)Tj /F17 1 Tf 0.561 0 TD ()Tj /F12 1 Tf 0.5729 0 TD [(2.63)-344.2()-341(13.20,)-345.4(P)-345.1(=)-341.1(0.080;)]TJ /F18 1 Tf 10.1271 0 TD ()Tj /F12 1 Tf 1.1339 0 TD (DBP:)Tj /F17 1 Tf 2.4348 0 TD ()Tj /F12 1 Tf 0.5729 0 TD [(13.00)-342.6()]TJ -22.6114 -1.2055 TD 0.011 Tc [(11)11(.46)]TJ /F15 1 Tf 2.6795 0 TD 0.0106 Tc (vs)Tj /F12 1 Tf 0.7877 0 TD 0 Tc (.)Tj /F17 1 Tf 0.734 0 TD ()Tj /F12 1 Tf 0.5848 0 TD [(5.)-13.2(6)-10.3(9)-517.6()-514.1(9)-10.3(.)-8.8(3)0(3)-14.7(,)-516(P)-518.2(=)-514.1(0)-10.3(.)-8.8(00)-14.7(8)-10.3(\))-9.1(,)-516(a)0(l)-11.2(t)-8.3(h)-12.1(o)-7.2(ug)-18.6(h)-513.3(t)-8.3(he)-13.8(r)-12(e)-515(w)-9.3(a)-10.6(s)-513.2(n)-8(o)]TJ -4.7861 -1.2114 TD (signi)Tj /F14 1 Tf 1.8858 0 TD ()Tj /F12 1 Tf 0.5311 0 TD [(cant)-333(dif)62.5(ference)-338.7(in)]TJ /F18 1 Tf 7.3701 0 TD ()Tj /F12 1 Tf 1.1339 0 TD [(mean)-336.2(SBP)-332.5(\()]TJ /F17 1 Tf 4.8338 0 TD ()Tj /F12 1 Tf 0.5729 0 TD [(4.94)-332.2()-329.1(9.53)]TJ /F15 1 Tf 4.8756 0 TD (vs)Tj /F12 1 Tf 0.7758 0 TD (.)Tj /F17 1 Tf 0.549 0 TD ()Tj /F12 1 Tf 0.5729 0 TD [(2.02)-332.2()]TJ -23.1008 -1.2114 TD [(9.37,)-281.3(P)-279.4(=)-275.4(0.253\))-280.1(or)]TJ /F18 1 Tf 7.746 0 TD ()Tj /F12 1 Tf 1.1339 0 TD [(mean)-282.5(DBP)-280.3(\()]TJ /F17 1 Tf 4.983 0 TD ()Tj /F12 1 Tf 0.5729 0 TD [(4.57)-284.5()-275.4(3.80)]TJ /F15 1 Tf 4.7204 0 TD (vs)Tj /F12 1 Tf 0.7758 0 TD (.)Tj /F17 1 Tf 0.4953 0 TD ()Tj /F12 1 Tf 0.5729 0 TD [(2.69)-278.5()-281.4(5.82,)]TJ -21.0002 -1.2114 TD [(P)-297.3(=)-305.2(0.192\))-298(between)-306.6(the)-302.6(two)-299.4(groups.)]TJ 1.2651 -1.2114 TD [(A)-196.2(t)0(o)20.2(t)15.6(a)13.3(l)-203.5(of)-187.7(5)13.5(2)-201.3(h)11.8(y)0(p)23.2(e)0(r)22.1(t)15.5(en)26(s)11.9(i)0(v)19.8(e)-198.7(p)12.8(a)13.3(ti)24.9(en)20.1(t)15.5(s)-202.9(w)14.6(e)0(r)22.1(e)-204.6(t)15.6(a)13.3(k)11.6(i)0(n)25.2(g)-204.4(a)13.3(n)0(t)25.4(i)0(h)21.2(y)16.4(p)12.7(e)0(r)22.1(t)0(e)25.7(n)0(s)21.8(i)15.3(ve)]TJ -1.2651 -1.2114 TD 0.0459 Tc [(drugs)-562.8(a)-0.5(n)-3.9(d)-556(21)-561.2(we)-3.6(re)-558.6(n)-3.9(o)2.8(t)-4.2(.)-559.6(Pati)-4.4(en)-3.9(ts)-562.8(who)-558.1(w)0.8(e)-3.6(r)4.1(e)-564.5(n)2.1(ot)-559.2(taki)-4.4(ng)]TJ 0 -1.2055 TD 0 Tc [(a)13.3(n)0(t)25.4(i)0(h)21.2(y)16.4(pe)22.9(r)11.9(t)0(e)25.7(n)0(s)21.8(i)0(v)25.7(e)-479.1(d)12.7(r)11.9(u)12.8(g)0(s)-467(h)17.8(ad)-469.3(h)11.8(i)15.3(gh)22.2(e)16.2(r)]TJ /F18 1 Tf 14.4477 0 TD ()Tj /F12 1 Tf 1.1219 0 TD [(SB)24.6(P)-476.4(\()]TJ /F17 1 Tf 2.399 0 TD ()Tj /F12 1 Tf 0.561 0 TD -0.0135 Tc [(10.)-13.5(1)9.2(0)-489.3()-485.8(2)-13.5(0)7.6(.)1.6(33)]TJ /F15 1 Tf 6.1646 0 TD 0 Tc (vs)Tj /F12 1 Tf 0.7459 0 TD (.)Tj /F17 1 Tf -25.4401 -1.2114 TD ()Tj /F12 1 Tf 0.561 0 TD -0.0135 Tc [(3.)-13.5(0)9.2(0)-262.6()-265(1)0(2)-13.5(.)9.2(68)-13.5(,)-253.4(P)-269.1(=)-265(0)0(.)-13.5(1)9.2(60\))-267.3(an)-13.5(d)]TJ /F18 1 Tf 11.2669 0 TD 0 Tc ()Tj /F12 1 Tf 1.1219 0 TD -0.0129 Tc [(DB)-12.9(P)-252.4(\()]TJ /F17 1 Tf 2.4348 0 TD 0 Tc ()Tj /F12 1 Tf 0.561 0 TD -0.0138 Tc [(12.)-13.8(5)8.9(0)-262.9()-271.3(11.4)-13.8(9)]TJ /F15 1 Tf 5.4962 0 TD -0.0133 Tc (vs)Tj /F12 1 Tf 0.746 0 TD 0 Tc (.)Tj /F17 1 Tf 0.4714 0 TD ()Tj /F12 1 Tf 0.561 0 TD [(5)13.5(.)15.1(75)-241.5()]TJ -23.2202 -1.2114 TD [(9)13.5(.)0(3)22.7(6)13.5(,)-193.8(P)-195.9(=)-197.8(0)13.5(.0)22.7(1)13.5(4)13.5(\))-200.1(t)15.6(h)11.8(a)13.3(n)-199(t)15.5(h)11.8(os)22.6(e)-192.7(t)0(a)22.9(k)11.6(in)25.2(g)-198.4(a)13.3(nt)25.4(ih)27.1(yp)23.2(er)22.1(te)25.7(ns)21.8(i)15.3(v)0(e)-188.3(d)12.8(r)11.9(u)12.8(gs)22.3(,)-193.8(b)0(u)23.4(t)-193.3(th)21.4(e)16.2(r)11.9(e)]TJ ET 0 0 0 0.7 k 45.354 251.943 504.567 0.28346 re f 45.354 84.529 504.567 0.28348 re f 45.354 234.538 504.567 0.28346 re f 45.354 272.239 504.567 0.28345 re f BT /F1 1 Tf 6.9999 0 0 6.9999 45.3543 258.1794 Tm 0 0 0 1 k [(TABLE)-301(1)-428(|)]TJ /F6 1 Tf 5.1349 0 TD [(Demographics)-307.9(and)-298.4(clinical)-300.6(characteristics)-305.7(of)-299.5(patients.)]TJ /F1 1 Tf 19.0816 -2.4864 TD [(Normotensive)-304.5(patients)-300.3(\(N)-306.4(=)-297.9(187\))-7715.3(Hypertensive)-308.5(patients)-300.3(\(N)-306.4(=)-297.9(73\))-8915.2(P)]TJ -24.2164 -2.4621 TD [(Age)-301.4(\(years\))]TJ /F6 1 Tf 27.4399 0 TD [(49.00)-300.1(\(38.00)]TJ /F22 1 Tf 5.4993 0 TD ()Tj /F6 1 Tf 0.5021 0 TD [(63.00\))-13683.8(65.00)-300.1(\(59.00)]TJ /F22 1 Tf 21.892 0 TD ()Tj /F6 1 Tf 0.5021 0 TD (74.00\))Tj /F1 1 Tf 13.1773 0 TD (<0.001)Tj -69.0127 -1.3526 TD [(Male)-299.9(sex)]TJ /F6 1 Tf 29.6185 0 TD [(96)-297.2(\(50.79\))-18037(38)-305.3(\(52.05\))-12926.5(0.855)]TJ /F1 1 Tf -29.6185 -1.3607 TD [(BMI)-300.9(\(kg/m)]TJ 5.2498 0 0 4.6661 79.8236 207.6661 Tm (2)Tj 6.9999 0 0 6.9999 82.715 204.548 Tm (\))Tj /F6 1 Tf 20.0211 0 TD [(21.36)-300.1(\(19.05)]TJ /F22 1 Tf 5.4993 0 TD ()Tj /F6 1 Tf 0.5021 0 TD [(23.87\))-304.1(\(n)-299.1(=)-297.9(184\))-9800.2(25.07)-300.1(\(21.42)]TJ /F22 1 Tf 22.1754 0 TD ()Tj /F6 1 Tf 0.494 0 TD [(27.96\))-304.1(\(n)-299.1(=)-306(69\))]TJ /F1 1 Tf 14.9834 0 TD (<0.001)Tj -69.0127 -1.3607 TD [(Smoking)-301.6(status)]TJ /F6 1 Tf 69.3043 0 TD (0.114)Tj /F1 1 Tf -68.3081 -1.3526 TD (Never)Tj /F6 1 Tf 28.347 0 TD [(161)-295.9(\(86.10\))-17761.7(55)-305.3(\(75.34\))]TJ /F1 1 Tf -28.347 -1.3607 TD (Former)Tj /F6 1 Tf 28.8977 0 TD [(11)-297.2(\(5.88\))-18589(8)-306.5(\(10.96\))]TJ /F1 1 Tf -28.8977 -1.3526 TD (Current)Tj /F6 1 Tf 28.8977 0 TD [(15)-297.2(\(8.02\))-18313.7(10)-305.3(\(13.70\))]TJ /F1 1 Tf -29.8939 -1.3607 TD (Alcoholism)Tj /F6 1 Tf 30.1693 0 TD [(7)-298.4(\(3.74\))-18864.4(9)-306.5(\(12.33\))]TJ /F1 1 Tf 39.135 0 TD (0.021)Tj -69.3043 -1.3526 TD [(SBP)-300.3(at)-299.9(hospital)-304.6(admission)-306.9(\(mmHg\))]TJ /F6 1 Tf 24.5323 0 TD [(120.00)-298.8(\(112.00)]TJ /F22 1 Tf 6.6008 0 TD ()Tj /F6 1 Tf 0.5021 0 TD [(127.25\))-302.8(\(n)-299.1(=)-297.9(186\))-8148(126.00)-298.8(\(122.00)]TJ /F22 1 Tf 22.1754 0 TD ()Tj /F6 1 Tf 0.494 0 TD [(138.00\))-302.8(\(n)-307.2(=)-297.9(73\))]TJ /F1 1 Tf 14.708 0 TD (<0.001)Tj -69.0127 -1.3607 TD [(DBP)-303.5(at)-299.9(hospital)-304.6(admission)-298.8(\(mmHg\))]TJ /F6 1 Tf 25.3584 0 TD [(75.00)-300.1(\(70.00)]TJ /F22 1 Tf 5.4993 0 TD ()Tj /F6 1 Tf 0.5021 0 TD [(81.00\))-304.1(\(n)-299.1(=)-297.9(186\))-9800.2(78.00)-300.1(\(75.00)]TJ /F22 1 Tf 22.1754 0 TD ()Tj /F6 1 Tf 0.494 0 TD [(85.00\))-304.1(\(n)-299.1(=)-306(73\))]TJ /F1 1 Tf 14.9834 0 TD (<0.001)Tj -69.0127 -1.3606 TD [(Total)-299.8(cholesterol)-306.4(\(mmol/L\))]TJ /F6 1 Tf 26.1926 0 TD [(4.60)-301.3(\(3.84)]TJ /F22 1 Tf 4.3897 0 TD ()Tj /F6 1 Tf 0.5021 0 TD [(5.50\))-297.2(\(n)-307.2(=)-297.9(152\))-11452.4(4.51)-301.3(\(4.04)]TJ /F22 1 Tf 22.1754 0 TD ()Tj /F6 1 Tf 0.494 0 TD [(5.21\))-305.3(\(n)-299.1(=)-297.9(64\))-9777.1(0.506)]TJ /F1 1 Tf -53.7539 -1.3526 TD [(Triglyceride)-305.9(\(mmol/L\))]TJ /F6 1 Tf 26.1926 0 TD [(0.98)-301.3(\(0.70)]TJ /F22 1 Tf 4.3897 0 TD ()Tj /F6 1 Tf 0.5021 0 TD [(1.34\))-297.2(\(n)-307.2(=)-297.9(152\))-11452.4(1.26)-301.3(\(1.00)]TJ /F22 1 Tf 22.1754 0 TD ()Tj /F6 1 Tf 0.494 0 TD [(1.95\))-305.3(\(n)-299.1(=)-297.9(64\))]TJ /F1 1 Tf 15.2588 0 TD (<0.001)Tj -69.0127 -1.3607 TD [(LDL)-298(\(mmol/L\))]TJ /F6 1 Tf 26.1926 0 TD [(2.70)-301.3(\(2.03)]TJ /F22 1 Tf 4.3897 0 TD ()Tj /F6 1 Tf 0.5021 0 TD [(3.54\))-297.2(\(n)-307.2(=)-297.9(152\))-11452.4(2.54)-301.3(\(2.04)]TJ /F22 1 Tf 22.1754 0 TD ()Tj /F6 1 Tf 0.494 0 TD [(3.28\))-305.3(\(n)-299.1(=)-297.9(64\))-9777.1(0.320)]TJ /F1 1 Tf -53.7539 -1.3526 TD [(HDL)-304(\(mmol/L\))]TJ /F6 1 Tf 27.7719 0 TD [(1.30)-301.3()-297.9(0.3)-302.6(\(n=152\))-14341.5(1.22)-301.3()-306(0.32)-301.3(\(n=64\))-11078.8(0.139)]TJ /F1 1 Tf -27.7719 -1.3607 TD (HOMA)Tj /F23 1 Tf 3.0939 0 TD ()Tj /F1 1 Tf 0.5021 0 TD (IR)Tj /F6 1 Tf 22.5966 0 TD [(1.46)-301.3(\(1.02)]TJ /F22 1 Tf 4.3897 0 TD ()Tj /F6 1 Tf 0.5021 0 TD [(2.06\))-297.2(\(n)-307.2(=)-297.9(101\))-11452.4(2.52)-301.3(\(1.46)]TJ /F22 1 Tf 22.1754 0 TD ()Tj /F6 1 Tf 0.494 0 TD [(3.38\))-305.3(\(n)-299.1(=)-297.9(51\))]TJ /F1 1 Tf 15.5503 0 TD (0.001)Tj /F4 1 Tf 6.5001 0 0 6.5001 45.3543 75.5717 Tm [(Data)-427.9(are)-429.8(the)-429.8(mean)-435.4()-427.5(standard)-435.6(deviation,)-434.9(median)-427.7(\(interquartile)-439.6(range\),)-431.6(or)-426.8(n)-428.4(\(%\).)-431.4(BMI,)-436.4(body)-427.6(mass)-431.2(index;)-429.9(DBP,)-430.8(diastolic)-436.2(blood)-427(pressure;)-438.2(HDL,)-432.8(high-densit)]TJ 67.0674 0 TD [(y)-426.3(lipoprotein;)-435.4(HOMA)]TJ /F11 1 Tf 8.9171 0 TD ()Tj /F4 1 Tf 0.5059 0 TD (IR,)Tj -76.4903 -1.3868 TD [(homeostasis)-304.5(model)-297.5(assessment)-308.7(of)-296.9(insulin)-301.3(resistance;)-305.1(LDL,)-302.3(low-density)-304.5(lipoprotein;)-304.5(SBP,)-299.7(systolic)-304.6(blood)-304.9(pressure.)-298.6(Signi)]TJ /F5 1 Tf 50.3511 0 TD ()Tj /F4 1 Tf 0.4361 0 TD [(cant)-303.5(P-values)-296.9(are)-299(emboldened.)]TJ ET 0 0 0 0.7 k 45.354 737.518 504.567 0.28345 re f BT /F6 1 Tf 6.9999 0 0 6.9999 45.3543 744.2644 Tm [(Zhong)-299.2(et)-300.5(al.)]TJ 48.0765 0 TD [(Washed)-306.8(Microbiota)-303.6(Transplantation)-301.7(Treats)-302.3(Hypertension)]TJ ET 45.354 42.803 504.567 0.22675 re f 45.354 42.803 504.567 0.22675 re f BT 6.9999 0 0 6.9999 45.3543 31.2945 Tm [(Frontiers)-306.1(in)-296.3(Cellular)-302.6(and)-306.5(Infection)-301.5(Microbiology)-499.5(|)-502.8(www.frontiersin.org)-24207.1(August)-303.6(2021)-505.2(|)-494.7(Volume)-307.7(11)-499.6(|)-494.7(Article)-305.6(679624)]TJ 35.7658 0 TD (4)Tj ET endstream endobj 68 0 obj<> endobj 69 0 obj<> endobj 70 0 obj<> endobj 71 0 obj<> endobj 72 0 obj<> endobj 73 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 74 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 75 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 76 0 obj<>/ColorSpace<>/Font<>/ProcSet[/PDF/Text/ImageC/ImageI]/Properties<>/ExtGState<>>> endobj 77 0 obj<>stream /GS1 gs BT /F12 1 Tf 9.5 0 0 9.5 45.3543 320.6551 Tm 0 0 0 1 k 0 Tc 0 Tw [(w)14.6(a)0(s)-350.8(n)0(o)-349.5(s)11.9(ig)25.7(ni)]TJ /F14 1 Tf 5.0248 0 TD ()Tj /F12 1 Tf 0.5192 0 TD [(ca)23.5(nt)-350.5(d)12.7(i)0(f)85.5(f)0(e)20.7(r)11.9(e)16.2(n)0(c)20.1(e)-359.8(i)15.3(n)]TJ /F18 1 Tf 7.2984 0 TD ()Tj /F12 1 Tf 1.1219 0 TD -0.0123 Tc [(me)-12.3(a)11.2(n)-372.4(S)-12.3(B)12.3(P)-375.3(\()]TJ /F17 1 Tf 4.8099 0 TD 0 Tc ()Tj /F12 1 Tf 0.561 0 TD -0.0138 Tc [(2)-13.8(.)8.9(69)-376.2()-378.7(10.3)-13.8(0)]TJ /F15 1 Tf 5.359 0 TD 0 Tc (vs)Tj /F12 1 Tf 0.746 0 TD (.)Tj /F17 1 Tf -25.4401 -1.2114 TD ()Tj /F12 1 Tf 0.561 0 TD -0.0135 Tc [(3.)-13.5(0)9.2(2)-232.7()-241.2(9)0(.)-13.5(1)9.2(6,)-237.1(P)-239.2(=)-235.2(0.)-13.5(8)9.2(96\))-237.4(o)-13.5(r)]TJ /F18 1 Tf 9.9779 0 TD 0 Tc ()Tj /F12 1 Tf 1.1219 0 TD -0.0123 Tc [(me)-12.3(a)11.2(n)-235.2(D)-12.3(B)10.7(P)-238(\()]TJ /F17 1 Tf 4.798 0 TD 0 Tc ()Tj /F12 1 Tf 0.561 0 TD [(3)13.5(.)0(4)22.7(7)-225.2()-221.7(5)13.5(.5)22.7(4)]TJ /F15 1 Tf 4.4817 0 TD -0.0133 Tc (vs)Tj /F12 1 Tf 0.746 0 TD 0 Tc (.)Tj /F17 1 Tf 0.4416 0 TD ()Tj /F12 1 Tf 0.561 0 TD -0.0139 Tc [(3.18)-239.1()]TJ -23.25 -1.2055 TD 0 Tc [(5)13.5(.)0(2)22.7(9)13.5(,)-289.3(P)-285.4(=)-287.3(0)0(.)22.6(8)13.5(38)21.1(\))-283.6(b)0(e)20.9(t)15.6(we)24.8(en)-278.3(th)27.4(e)-288.2(t)0(w)24.2(o)-287.7(gr)22.3(ou)23.4(p)12.7(s)-286.5(\()]TJ /F21 1 Tf 0 0 0 rg 16.5483 0 TD -0.014 Tc [(Fi)-14(g)8.1(u)0.9(re)-303.1(2)-14(B)]TJ /F12 1 Tf 0 0 0 1 k 4.0401 0 TD 0 Tc (\).)Tj -19.3233 -1.2114 TD 0.0293 Tc [(With)-525.8(regard)-524.9(to)-527(the)-527.4(c)-2.3(omplicat)]TJ 13.3855 0 TD 0.0296 Tc [(ions)-525.4(of)-526.8(hypertension,)-528.2(4)1.3(4)]TJ -14.6506 -1.2114 TD 0.0279 Tc [(h)3.9(y)2.5(pe)8.3(rte)8.3(n)2(si)7.4(ve)-522.9(pa)5.4(tient)7.6(s)-521.2(ha)5.4(d)-520.3(a)-0.6(t)-523.5(l)]TJ 13.4213 0 TD 0.0247 Tc [(east)-526.7(one)-526.1(c)-0.9(omplication)-526.4(\()-2.3(e.g.,)]TJ -13.4213 -1.2114 TD 0 Tc [(str)-8.4(oke,)-513.4(coron)-12.4(ary)-507.4(hear)-12.5(t)-503.6(dise)-9.5(ase,)-510.5(or)-508.6(heart)-516.1(fail)-9.2(ure\))-511.3(and)-507.1(29)-510(had)]TJ T* (none.)Tj /F18 1 Tf 2.6556 0 TD ()Tj /F12 1 Tf 1.1339 0 TD (SBP,)Tj /F18 1 Tf 2.2677 0 TD ()Tj /F12 1 Tf 1.1339 0 TD (DBP,)Tj /F18 1 Tf 2.5303 0 TD ()Tj /F12 1 Tf 1.1339 0 TD [(mean)-437.7(SBP,)-436.7(and)]TJ /F18 1 Tf 6.8449 0 TD ()Tj /F12 1 Tf 1.1339 0 TD [(mean)-437.7(DBP)-435.5(were)]TJ -18.8339 -1.2114 TD [(not)-292.1(signi)]TJ /F14 1 Tf 3.5209 0 TD ()Tj /F12 1 Tf 0.5311 0 TD [(cantly)-293.4(dif)56.5(ferent)-295.8(between)-294.7(hypertensive)-295.1(patients)-295.4(with)-294.8(or)]TJ -4.052 -1.2114 TD [(without)-303.6(complications)-306.1(\()]TJ /F21 1 Tf 0 0 0 rg 9.6199 0 TD [(Figure)-301.7(2C)]TJ /F12 1 Tf 0 0 0 1 k 4.1774 0 TD (\).)Tj /F1 1 Tf 11.9999 0 0 11.9999 45.3543 206.1921 Tm [(Ef)59.9(fect)-302.8(of)-302.4(the)-302(Delivery)-303.4(Route)-302.9(of)-297.6(WMT)-302.6(on)]TJ 0 -1.0441 TD [(Blood)-302.5(Pressure)-301(in)-300.9(Hypertensive)-306.3(Patients)]TJ /F12 1 Tf 9.5 0 0 9.5 45.3543 182.1543 Tm [(We)-197.4(a)13.3(l)0(s)17.2(o)-198.2(ex)18.7(pl)18.1(or)22.6(ed)-197.9(w)14.6(h)0(e)16(t)0(h)21.4(e)0(r)-192.7(t)0(h)21.4(e)-204.6(an)17.2(ti)24.9(hy)16.3(p)12.8(e)0(r)16.1(t)0(e)19.8(n)0(s)21.8(i)0(v)19.8(e)-204.6(ef)86.4(fe)14.8(ct)-189.1(of)-193.7(WM)15(T)-203.6(w)14.6(as)]TJ 0 -1.2114 TD [(af)83.5(fe)20.7(ct)19.8(ed)-376.9(by)-372.8(th)21.4(e)-383.7(d)12.8(el)21.5(iv)19.8(er)16.1(y)-383.4(r)11.9(ou)17.4(t)15.6(e)0(.)-374.5(A)0(m)19(o)0(n)20.5(g)-383.4(h)11.8(y)0(p)17.2(e)0(r)22.1(t)0(e)19.8(n)0(s)15.8(i)15.3(ve)-373.2(pa)20.1(ti)18.9(en)20.1(ts)21.5(,)-384.7(3)0(7)]TJ 0 -1.2055 TD [(r)11.9(e)0(c)20.4(e)0(i)19.6(v)0(e)20.6(d)-220(WM)20.9(T)]TJ /F15 1 Tf 6.081 0 TD -0.0133 Tc [(vi)-13.3(a)]TJ /F12 1 Tf 1.3905 0 TD 0 Tc [(th)15.4(e)-216.6(u)12.7(pp)19.5(er)-210.6(ga)17.8(s)11.9(t)0(r)21.5(o)0(i)20(n)0(t)19.5(e)0(s)22.1(t)0(i)18.9(n)0(a)17.2(l)-215.5(tr)21.5(ac)17.5(t)-217.2(a)13.3(nd)-210.1(36)-205.7(re)16.1(ce)20.4(iv)19.8(ed)]TJ -7.4715 -1.2114 TD [(WM)20.9(T)]TJ /F15 1 Tf 2.8943 0 TD [(vi)20.7(a)]TJ /F12 1 Tf 1.6232 0 TD [(th)15.4(e)-443.3(l)0(o)16(w)14.6(er)-437.4(ga)17.8(s)11.9(t)0(r)15.5(o)0(i)26(n)0(t)19.5(e)0(s)16.1(t)0(i)24.9(n)0(a)17.2(l)-448.2(tr)21.5(ac)17.5(t.)-434.8(Co)22.1(mp)19.1(ar)19.2(ed)-442.5(w)14.6(i)0(t)18.9(h)-447.7(th)21.4(e)]TJ -4.5175 -1.2114 TD [(fo)21.2(r)11.9(m)0(e)16.6(r)11.9(,)-408.6(t)0(h)21.4(e)-413.5(la)24.6(tt)19.2(er)-401.6(le)21.5(d)-405(t)0(o)-397.5(a)-410.4(si)21.3(gn)20.3(i)]TJ /F14 1 Tf 12.8305 0 TD ()Tj /F12 1 Tf 0.5252 0 TD [(ca)23.5(nt)19.5(ly)-396(hi)15.2(gh)22.2(er)]TJ /F18 1 Tf 5.6752 0 TD ()Tj /F12 1 Tf 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[(W)-10.7(M)0(T)-518.1(h)-12.1(ad)-523(a)-511.9(b)-7.3(l)-12.6(o)-7.3(o)-7.3(d)-512.4(p)-11.1(r)0(e)-13.7(s)0(s)-18(u)0(r)-17.1(e)-7.7(-l)-10.7(o)-13.2(w)0(e)-11(r)-12(i)-8.5(n)-8(g)-514.7(e)-7.7(f)58.3(f)-7.4(e)-13.7(c)-7.7(t)-515.6(i)0(n)-517.8(h)-12.1(y)-7.5(p)0(e)-12.9(r)-12(t)-8.3(e)-7.7(n)-8(s)0(i)-14.5(v)-7.5(e)]TJ 0 -1.2055 TD 0.0121 Tc [(pat)3.8(i)3.6(en)4.1(ts)-507.1(\(es)12.1(p)-5(ec)4.4(ial)5.5(l)-0.5(y)-508.6(i)3.6(n)-509.1(t)3.8(ho)4.8(se)-508.8(who)-508.4(u)1(n)4.1(d)1(e)4.4(r)0.1(wen)4.1(t)-509.4(WMT)]TJ /F15 1 Tf 22.6532 0 TD 0.0106 Tc (via)Tj /F12 1 Tf 1.7366 0 TD 0.0102 Tc (the)Tj -24.3898 -1.2114 TD 0.0433 Tc [(lower)-547.5(g)6(astroint)5.1(est)5.1(i)-1(nal)-542.2(t)-0.8(ract)-537.9(and)-540.7(t)-0.8(hose)-543.3(who)-542.8(d)2.3(id)-540.7(not)-543.9(u)2.3(se)]TJ T* 0 Tc [(antihypertensive)-473.8(drugs\))-474.5(but)-474.3(WMT)-469.1(had)-469.4(virtually)-472.6(no)-468.8(ef)56.5(fect)-466.8(on)]TJ T* [(the)-439.8(blood)-439.3(pressure)-449.5(of)-438.3(normotensive)-445.9(patients.)-447.4(This)-439(is)-444.2(the)]TJ /F14 1 Tf 24.0974 0 TD ()Tj /F12 1 Tf 0.5311 0 TD (rst)Tj -24.6285 -1.2114 TD [(clinical)-332.9(study)-330.5(to)-325.9(determine)-339.3(the)-326.5(antihypertensive)-336.5(ef)62.5(fect)-335.5(of)-325(WMT)]TJ T* [(in)-470.1(hypertensive)-474.1(patients.)-471.3(Our)-471.7(data)-470.3(suggest)-471.8(that)-468.9(manipulation)]TJ T* 0.0186 Tc [(of)-519.9(th)-5.4(e)-514.3(g)-0.8(u)-4.5(t)-514.9(m)-4.9(i)4.1(cr)-5.3(obiota)-517.1(could)-523.6(b)-0.6(e)-514.3(a)-523.1(new)-515.8(t)-1.7(hera)-3.9(peutic)-520.2(avenue)]TJ 0 -1.2055 TD 0 Tc [(for)-301.1(hypertension.)]TJ 1.2651 -1.2114 TD [(Several)-330(intervention)-332.7(studies)-333.3(have)-324.3(shown)-335(that)-325.7(blood)-325.9(pressure)]TJ -1.2651 -1.2114 TD [(in)-344.8(hypertensive)-348.8(animal)-342.3(models)-348.6(can)-342.6(be)-349.1(modi)]TJ /F14 1 Tf 17.9209 0 TD ()Tj /F12 1 Tf 0.5311 0 TD [(ed)-347(by)-343(altering)-349.7(the)]TJ -18.452 -1.2114 TD [(gut)-331.3(microbiota)-333.6(\(e.g.,)-337(using)-333.6(antibiotics,)-336.6(prebiotics,)-331.9(or)-335.5(probiotics\))]TJ T* (\()Tj 0 0 0 0.7 k 0.3461 0 TD [(Yang)-308.2(et)-302.5(al.,)-309.2(2015)]TJ 0 0 0 1 k 6.7434 0 TD (;)Tj 0 0 0 0.7 k 0.5252 0 TD [(Marques)-305.4(et)-308.4(al.,)-309.2(2017)]TJ 0 0 0 1 k 8.1757 0 TD (;)Tj 0 0 0 0.7 k 0.5311 0 TD [(Wang)-305.3(et)-308.4(al.,)-309.2(2017)]TJ 0 0 0 1 k 7.0836 0 TD [(\).)-310.3(For)]TJ -23.4051 -1.2114 TD [(example,)-216.7(Yang)-212.7(and)-214.7(colleagues)-216(showed)-214.5(that)-212.3(oral)-209.5(administration)-216.9(of)]TJ 0 -1.2055 TD [(the)-302.6(antibiotic)-303.9(minocycline)-310(for)-307.1(4)-302.8(weeks)-299.6(in)-309(a)-303(hypertensive)-307(animal)]TJ 0 -1.2114 TD [(model)-396.3(restored)-394.3(and)-399.7(reshaped)-394.5(the)-398.1(microbiota)-393.3(composition)-401.9(and)]TJ T* [(l)-6.6(o)-7.2(w)-9.3(e)-7.7(r)-12(e)-7.7(d)-518.4(b)-7.3(l)-6.6(o)-13.2(o)-7.3(d)-518.4(pr)-17.1(e)-7.7(s)-12(su)-17.1(re)-526.9(si)-14.5(g)-7.5(n)-8(i)]TJ /F14 1 Tf 12.3709 0 TD ()Tj /F12 1 Tf 0.5371 0 TD 0.008 Tc [(cantly)-512.7(\()]TJ 0 0 0 0.7 k 3.318 0 TD 0.0087 Tc [(Yang)-506(et)-506.9(al.)-6(,)-507.3(2)8.7(0)-6(15)]TJ 0 0 0 1 k 7.4596 0 TD 0.0082 Tc [(\).)-513.8(In)]TJ -23.6856 -1.2114 TD 0 Tc [(ad)-15.7(di)-13.7(ti)-10.9(o)-7.2(n)-8(,)-510.1(h)0(i)-14.6(g)-7.5(h)]TJ /F14 1 Tf 6.4391 0 TD ()Tj /F12 1 Tf 0.5371 0 TD [(be)-9(r)-513.2(a)-10.6(nd)-520.4(ac)-12.3(e)-7.7(t)0(a)-12.9(t)0(e)-517.3(s)0(u)-11.2(p)-11.1(pl)-11.8(e)-7.7(m)0(e)-13.3(n)-8(ta)-12.9(ti)-10.9(o)-7.3(n)-509.3(h)-12.1(a)0(v)-12.1(e)-509(b)-7.3(e)-7.7(e)-7.7(n)]TJ ET 0 0 0 0.7 k 45.354 717.505 m 549.921 717.505 l 549.694 717.222 l 45.581 717.222 l f* 549.921 717.505 m 549.921 460.97 l 549.694 461.197 l 549.694 717.222 l f* 549.921 460.97 m 45.354 460.97 l 45.581 461.197 l 549.694 461.197 l f* 45.354 460.97 m 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0 1 k [(FIGURE)-299.4(2)]TJ /F6 1 Tf 5.0053 0 TD (|)Tj /F1 1 Tf 0.6479 0 TD -0.0156 Tc [(\(A)-15.6(\))]TJ /F6 1 Tf 1.5145 0 TD 0 Tc [(Ef)87.9(fe)31.1(ct)-276.2(o)17.5(f)-292.6(WM)27.2(T)-282.2(o)17.5(n)-287(b)0(l)28.2(o)0(o)26.8(d)-286.5(pr)25.5(e)16(s)0(s)26.6(u)0(r)25(e)-283.7(in)-272(hy)25.2(pe)29.1(rt)28(e)16(n)0(s)30(i)0(v)27.6(e)-291.8(pa)29.1(t)15.6(i)0(e)31(n)0(t)28.3(s)-290.4(w)18.2(h)0(o)-277.7(u)0(n)33.4(d)0(e)21(r)20.4(we)26(nt)-271.4(WM)27.2(T)-290.3(t)15.6(o)-282.2(t)0(r)28(e)0(a)23.8(t)-284(or)21.7(g)17.5(a)16(ni)27.7(c)-283.7(d)0(i)28.2(s)0(e)25.2(a)15.9(se)-274.5(o)17.5(r)-287.3(fu)27.8(nc)28.6(ti)22.5(o)17.5(n)0(a)28.6(l)-284.7(di)28.2(se)25.2(a)16(s)0(e)25.2(.)]TJ /F1 1 Tf 52.4905 0 TD -0.0162 Tc (\(B\))Tj /F6 1 Tf 1.5388 0 TD 0 Tc [(E)16.1(f)79.9(fe)23(c)16(t)-284(of)-275.2(WM)27.2(T)-282.2(o)0(n)]TJ -61.197 -1.3526 TD [(bl)28.2(o)17.5(o)17.5(d)-286.5(pr)25.5(es)25.2(s)17.4(u)0(r)25(e)-283.7(in)-272(hy)25.2(pe)29.1(rt)28(e)16(n)0(s)21.9(i)0(v)27.6(e)-283.7(pa)29.1(t)15.6(i)0(e)22.9(n)0(t)28.3(s)-282.3(ta)23.5(ki)29.1(ng)-269.6(o)17.5(r)-287.3(no)22(t)-284(t)15.6(a)16(k)0(i)29.1(n)0(g)-277.7(a)15.9(nt)28.3(ih)27.7(yp)25.7(e)16(r)0(t)27.9(e)16(ns)21.9(iv)27.6(e)-283.7(d)0(r)25.5(u)20.8(gs)26.7(.)]TJ /F1 1 Tf 34.7291 0 TD -0.0156 Tc [(\(C)-15.6(\))]TJ /F6 1 Tf 1.5793 0 TD 0 Tc [(E)16.1(f)71.8(fe)31.1(c)15.9(t)-292.1(o)17.5(f)-284.5(WM)27.2(T)-290.3(o)17.5(n)-287(b)0(l)28.2(o)17.5(od)-277.2(pr)33.6(es)25.2(su)30(re)-271.4(in)-272(hy)25.2(pe)29.1(rt)28(en)28.6(si)24.3(ve)-271.2(pa)29.1(ti)22.5(e)16(n)0(t)28.3(s)-282.3(wi)25.1(t)15.6(h)-287(or)-269.9(wi)25.1(t)15.6(h)0(o)22(u)20.8(t)]TJ -36.3084 -1.3607 TD [(c)16(o)17.5(mp)25.2(li)30(ca)23.8(t)15.6(i)0(o)24.4(n)20.8(s.)]TJ /F1 1 Tf 6.2282 0 TD [(\(D)25.7(\))]TJ /F6 1 Tf 1.5874 0 TD [(E)16.1(f)79.9(fe)23(c)16(t)-284(of)-275.2(t)15.6(h)0(e)-271.1(d)0(e)29.1(l)0(i)30(v)0(e)20.4(r)20.4(y)-287.1(ro)29.8(ut)20.2(e)-283.7(o)17.5(f)-284.5(W)0(M)27.2(T)-290.3(o)17.5(n)-287(bl)28.2(oo)26.8(d)-286.5(p)0(r)25.5(e)15.9(s)17.3(s)0(u)21.9(r)20.4(e)-291.8(i)0(n)-272(h)0(y)33.3(p)0(e)21(r)20.4(te)23.5(ns)30(iv)27.6(e)-283.7(p)0(a)21(t)15.6(ie)31(nt)28.3(s.)-271.5(Da)28.8(ta)-276.2(a)15.9(r)0(e)-271.4(t)0(h)28.3(e)-291.8(me)28(a)16(n)0(.)]TJ /F18 1 Tf 41.0626 0 TD ()Tj /F6 1 Tf 1.1177 0 TD [(S)17.6(B)0(P)27.5(:)-288.8(sy)29.9(st)24.9(o)17.5(l)0(i)21.9(c)-283.7(bl)28.2(o)17.4(o)0(d)-277.2(p)0(r)25.5(e)16(s)17.3(s)0(u)30(r)0(e)-279.5(a)16(t)-284(h)0(o)30.1(s)0(p)22.4(i)0(t)30.6(a)15.9(l)]TJ -49.9959 -1.3606 TD [(di)28.2(s)17.4(c)16(ha)28.6(rg)21.7(e)-283.7(m)0(i)27.1(n)0(u)25.3(s)-282.3(s)17.3(y)0(s)21.8(t)15.6(o)17.5(l)0(i)30(c)-291.8(bl)28.2(o)17.5(o)0(d)-277.2(p)0(r)33.6(e)0(s)25.2(s)17.3(ur)25(e)-283.7(a)0(t)-276.2(h)0(o)30.1(s)0(p)22.4(i)0(t)30.6(a)16(l)-284.7(a)0(d)21(m)20.2(is)24.3(s)17.4(i)0(o)24.4(n)0(;)]TJ /F18 1 Tf 26.2331 0 TD ()Tj /F6 1 Tf 1.1258 0 TD [(DB)30.9(P:)-271.3(di)28.2(as)25.2(t)15.6(o)0(l)24.4(i)0(c)-268.7(b)0(l)28.2(o)0(o)26.8(d)-286.5(pr)25.5(e)16(s)17.4(su)21.9(re)-271.4(a)16(t)-284(ho)22(s)17.4(p)0(i)28.2(t)15.6(al)-276.8(di)28.2(s)17.3(c)15.9(ha)20.5(r)20.4(g)0(e)-274.4(m)0(i)27.1(n)0(u)25.3(s)-282.3(di)28.2(a)15.9(s)0(t)24.9(o)17.5(li)21.9(c)-283.7(b)0(l)28.2(o)17.5(od)-277.2(pr)25.5(e)16(s)17.3(su)21.9(r)20.4(e)-291.8(a)16(t)-284(ho)30.1(sp)22.4(it)30.6(a)16(l)]TJ -27.3589 -1.3526 TD -0.016 Tc [(ad)-16(m)9.2(i)-16(s)16.4(s)-16(i)8.3(o)1.5(n)-16(;)]TJ /F18 1 Tf 4.7299 0 TD 0 Tc ()Tj /F6 1 Tf 1.1177 0 TD [(me)28(a)16(n)-287(SB)27.5(P:)-271.3(me)28(an)-279.2(s)17.3(y)0(s)29.9(t)15.6(ol)24.4(ic)-268.7(bl)28.2(oo)26.8(d)-286.5(p)0(r)25.5(e)16(ss)26.6(ur)25(e)-283.7(a)16(ft)22.6(e)16(r)-287.3(t)15.6(h)0(e)]TJ /F7 1 Tf 21.2197 0 TD ()Tj /F6 1 Tf 0.4212 0 TD [(rs)21.6(t)-284(W)0(M)27.1(T)-282.2(mi)27.1(nu)25.3(s)-282.3(m)0(e)28(a)0(n)-279.2(s)17.4(ys)29.9(t)15.6(o)0(l)24.4(i)0(c)-268.7(b)0(l)28.2(o)0(o)26.8(d)-286.5(pr)25.5(e)16(s)0(s)26.6(u)0(r)25(e)-283.7(be)29.1(fo)24.5(re)-271.4(t)15.6(h)0(e)]TJ /F7 1 Tf 23.6414 0 TD ()Tj /F6 1 Tf 0.4212 0 TD [(rs)21.6(t)-284(W)0(M)27.2(T)17.4(;)]TJ /F18 1 Tf 4.1387 0 TD ()Tj /F6 1 Tf 1.1177 0 TD [(me)19.9(a)16(n)-287(DB)30.9(P)17.6(:)-288.8(me)28(an)-271.1(di)28.2(as)25.2(t)15.6(o)0(l)24.4(i)0(c)-268.7(b)0(l)28.2(o)0(o)26.8(d)]TJ -56.8073 -1.3607 TD [(pr)33.6(es)25.2(s)17.4(u)0(r)25(e)-283.7(af)23(t)15.6(e)16(r)-287.3(t)15.6(he)]TJ /F7 1 Tf 7.5808 0 TD ()Tj /F6 1 Tf 0.4293 0 TD [(rs)29.7(t)-284(W)0(M)27.2(T)-290.3(m)20.2(i)0(n)27.7(u)0(s)-277.8(m)0(e)28(a)16(n)-287(d)0(i)28.2(a)16(st)24.9(o)17.5(l)0(i)30(c)-291.8(bl)28.2(o)17.5(o)0(d)-277.2(p)0(r)33.6(e)0(s)25.2(s)0(u)30(r)0(e)-271.4(b)0(e)21(f)0(o)32.6(r)0(e)-271.4(t)0(h)28.3(e)]TJ /F7 1 Tf 23.9491 0 TD ()Tj /F6 1 Tf 0.4212 0 TD [(rs)29.7(t)-284(W)0(M)27.2(T)0(.)-279.5(W)0(M)27.2(T)17.5(,)-288.8(w)18.2(a)16(s)0(h)21.9(e)16(d)-286.5(m)0(i)27.1(c)16(ro)29.8(bi)28.2(ot)25(a)-283.7(t)0(r)28(a)0(n)20.5(s)17.4(pl)28.2(a)16(n)0(t)28.3(a)0(t)23.5(i)0(o)32.5(n)0(.)-276.2(*)0(P)28.5(<)18(0.)20.2(0)17.5(5)17.5(,)-288.8(**)30(P<)27.4(0.)28.3(01)26.8(.)]TJ ET 0 0 0 0.7 k 45.354 420.208 504.567 0.28345 re f 45.354 338.343 504.567 0.22678 re f 146.324 402.803 m 45.354 402.803 l 45.354 403.087 l 146.324 403.087 l f* 146.324 402.803 403.597 0.28348 re f BT /F1 1 Tf 6.9999 0 0 6.9999 45.3543 426.5007 Tm 0 0 0 1 k [(TABLE)-301(2)-428(|)]TJ /F6 1 Tf 5.1349 0 TD [(Ef)63.6(fect)-301.8(of)-299.5(WMT)-303.7(on)-302(hypertension-related)-306.5(risk)-305.7(factors)-295.2(in)-304.4(hypertensive)-306.2(patients.)]TJ /F1 1 Tf 9.6947 -2.4864 TD [(Before)-298.3(the)]TJ /F25 1 Tf 5.2563 0 TD ()Tj /F1 1 Tf 0.5993 0 TD [(rst)-304.2(WMT)-3230.5(After)-300.9(the)]TJ /F25 1 Tf 11.6465 0 TD ()Tj /F1 1 Tf 0.5993 0 TD [(rst)-304.2(WMT)-3740.8(P)-3310.7(Before)-306.4(the)]TJ /F25 1 Tf 16.9839 0 TD ()Tj /F1 1 Tf 0.5993 0 TD [(rst)-304.2(WMT)-2428.7(After)-300.9(the)-308.1(second)-300.2(WMT)-2939(P)]TJ -50.5143 -2.4702 TD [(BMI)-300.9(\(kg/m)]TJ 5.2498 0 0 4.6661 79.8236 394.9228 Tm (2)Tj 6.9999 0 0 6.9999 82.715 391.8046 Tm (\))Tj /F6 1 Tf 9.8242 0 TD [(24.71)-300.1()-297.9(3.96)-301.3(\(n)-299.1(=)-306(68\))-3459.8(24.43)-300.1()-306(4.23)-301.3(\(n)-299.1(=)-297.9(68\))-2739(0.284)-2737.9(25.34)-300.1()-297.9(3.69)-301.3(\(n)-299.1(=)-306(37\))-3459.8(25.25)-300.1()-306(3.98)-301.3(\(n)-299.1(=)-297.9(37\))-2739(0.821)]TJ /F1 1 Tf -15.1616 -1.3526 TD (HOMA)Tj /F23 1 Tf 3.0939 0 TD ()Tj /F1 1 Tf 0.5021 0 TD (IR)Tj /F6 1 Tf 10.8285 0 TD [(2.38)-301.3(\(1.48)]TJ /F22 1 Tf 4.3978 0 TD ()Tj /F6 1 Tf 0.5021 0 TD [(3.18\))-297.2(\(n)-299.1(=)-306(26\))-2002(2.72)-301.3(\(1.44)]TJ /F22 1 Tf 12.173 0 TD ()Tj /F6 1 Tf 0.494 0 TD [(4.97\))-305.3(\(n)-299.1(=)-297.9(26\))-2010.1(0.112)-2000.9(2.76)-301.3(\(1.53)]TJ /F22 1 Tf 16.6599 0 TD ()Tj /F6 1 Tf 0.5021 0 TD [(3.68\))-297.2(\(n)-299.1(=)-306(20\))-2002(2.61)-301.3(\(1.28)]TJ /F22 1 Tf 12.173 0 TD ()Tj /F6 1 Tf 0.494 0 TD [(4.79\))-305.3(\(n)-299.1(=)-297.9(20\))-2010.1(0.852)]TJ /F1 1 Tf -61.8207 -1.3607 TD [(Total)-299.8(cholesterol)-306.4(\(mmol/L\))]TJ /F6 1 Tf 15.4369 0 TD [(4.70)-301.3()-297.9(0.93)-301.3(\(n)-299.1(=)-297.9(44\))-4018.7(4.75)-301.3()-306(0.96)-301.3(\(n)-299.1(=)-297.9(44\))-3014.4(0.716)-2000.9(4.54)-301.3(\(3.92)]TJ /F22 1 Tf 33.2145 0 TD ()Tj /F6 1 Tf 0.5021 0 TD [(5.64\))-297.2(\(n)-299.1(=)-306(28\))-2002(4.22)-301.3(\(3.81)]TJ /F22 1 Tf 12.173 0 TD ()Tj /F6 1 Tf 0.494 0 TD [(4.78\))-305.3(\(n)-299.1(=)-297.9(28\))-2010.1(0.175)]TJ /F1 1 Tf -61.8207 -1.3526 TD [(Triglyceride)-305.9(\(mmol/L\))]TJ /F6 1 Tf 14.4246 0 TD [(1.37)-301.3(\(1.08)]TJ /F22 1 Tf 4.3978 0 TD ()Tj /F6 1 Tf 0.5021 0 TD [(2.14\))-297.2(\(n)-299.1(=)-306(44\))-2002(1.50)-301.3(\(0.93)]TJ /F22 1 Tf 12.173 0 TD ()Tj /F6 1 Tf 0.494 0 TD [(2.09\))-305.3(\(n)-299.1(=)-297.9(44\))-2010.1(0.809)-2000.9(1.38)-301.3(\(1.14)]TJ /F22 1 Tf 16.6599 0 TD ()Tj /F6 1 Tf 0.5021 0 TD [(2.51\))-297.2(\(n)-299.1(=)-306(28\))-2002(1.31)-301.3(\(0.90)]TJ /F22 1 Tf 12.173 0 TD ()Tj /F6 1 Tf 0.494 0 TD [(2.38\))-305.3(\(n)-299.1(=)-297.9(28\))-2010.1(0.113)]TJ /F1 1 Tf -61.8207 -1.3607 TD [(HDL)-304(\(mmol/L\))]TJ /F6 1 Tf 14.4246 0 TD [(1.18)-301.3(\(1.02)]TJ /F22 1 Tf 4.3978 0 TD ()Tj /F6 1 Tf 0.5021 0 TD [(1.38\))-297.2(\(n)-299.1(=)-306(44\))-2002(1.21)-301.3(\(1.07)]TJ /F22 1 Tf 12.173 0 TD ()Tj /F6 1 Tf 0.494 0 TD [(1.39\))-305.3(\(n)-299.1(=)-297.9(44\))-2010.1(0.890)-2000.9(1.19)-301.3(\(0.98)]TJ /F22 1 Tf 16.6599 0 TD ()Tj /F6 1 Tf 0.5021 0 TD [(1.35\))-297.2(\(n)-299.1(=)-306(28\))-2002(1.15)-301.3(\(1.01)]TJ /F22 1 Tf 12.173 0 TD ()Tj /F6 1 Tf 0.494 0 TD [(1.32\))-305.3(\(n)-299.1(=)-297.9(28\))-2010.1(0.269)]TJ /F1 1 Tf -61.8207 -1.3607 TD [(LDL)-298(\(mmol/L\))]TJ /F6 1 Tf 14.4246 0 TD [(2.62)-301.3(\(2.07)]TJ /F22 1 Tf 4.3978 0 TD ()Tj /F6 1 Tf 0.5021 0 TD [(3.33\))-297.2(\(n)-299.1(=)-306(44\))-2002(2.79)-301.3(\(2.15)]TJ /F22 1 Tf 12.173 0 TD ()Tj /F6 1 Tf 0.494 0 TD [(3.43\))-305.3(\(n)-299.1(=)-297.9(44\))-2010.1(0.432)-2000.9(2.46)-301.3(\(2.07)]TJ /F22 1 Tf 16.6599 0 TD ()Tj /F6 1 Tf 0.5021 0 TD [(3.34\))-297.2(\(n)-299.1(=)-306(28\))-2002(2.34)-301.3(\(1.96)]TJ /F22 1 Tf 12.173 0 TD ()Tj /F6 1 Tf 0.494 0 TD [(2.94\))-305.3(\(n)-299.1(=)-297.9(28\))-2010.1(0.050)]TJ /F4 1 Tf 6.5001 0 0 6.5001 45.3543 329.3291 Tm [(Data)-358.1(are)-360(the)-360(mean)-356.9()-357.7(standard)-357.1(deviation)-364.8(or)-357(median)-358(\(interquartile)-361.1(range\).)-361.8(BMI,)-357.9(body)-357.8(mass)-361.4(index;)-360.2(WMT,)-359.5(washed)-357(microbiota)-365.5(transplantation;)-363.8(HDL,)-354.3(high-den)]TJ 66.2599 0 TD [(sity)-365.3(lipoprotein;)-356.9(HOMA)]TJ /F11 1 Tf 9.7246 0 TD ()Tj /F4 1 Tf 0.5059 0 TD (IR,)Tj -76.4903 -1.3868 TD [(homeostasis)-304.5(model)-297.5(assessment)-308.7(of)-296.9(insulin)-301.3(resistance;)-305.1(LDL,)-302.3(low-density)-304.5(lipoprotein.)]TJ ET 0 0 0 0.7 k 45.354 737.518 504.567 0.28345 re f BT /F6 1 Tf 6.9999 0 0 6.9999 45.3543 744.2644 Tm [(Zhong)-299.2(et)-300.5(al.)]TJ 48.0765 0 TD [(Washed)-306.8(Microbiota)-303.6(Transplantation)-301.7(Treats)-302.3(Hypertension)]TJ ET 45.354 42.803 504.567 0.22675 re f 45.354 42.803 504.567 0.22675 re f BT 6.9999 0 0 6.9999 45.3543 31.2945 Tm 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[(mult)5.4(ispecie)6(s)-517.5(gut-microbiota)-510.1(t)-0.6(ran)5.7(s)-4.2(plan)5.7(tat)5.4(i)-0.8(on,)-514.3(F)2.6(MT)-512.1(has)-511.5(b)0.5(een)]TJ T* 0.0584 Tc [(reported)-555.5(to)-557.6(h)4.6(a)-5.9(ve)-558(markedly)-557.8(antihypertens)4.7(i)-3.9(ve)-564(ef)58.4(fects)-562.3(i)2.1(n)]TJ ET 0 0 0 0.7 k 45.354 717.505 m 549.921 717.505 l 549.694 717.222 l 45.581 717.222 l f* 549.921 717.505 m 549.921 195.08 l 549.694 195.364 l 549.694 717.222 l f* 549.921 195.08 m 45.354 195.08 l 45.581 195.364 l 549.694 195.364 l f* 45.354 195.08 m 45.354 717.505 l 45.581 717.222 l 45.581 195.364 l f* /EmbeddedDocument /MC11 BDC /Document /MC12 BDC q 101.194 692.36 134.904 -138.432 re W n q 135.276001 0 0 138.815994 100.84201 553.902039 cm /Im15 Do Q Q q 235.762 692.36 135.24 -138.432 re W n q 135.276001 0 0 138.815994 235.752014 553.902039 cm /Im16 Do Q Q q 370.666 692.36 134.865 -138.432 re W n q 135.276001 0 0 138.815994 370.662018 553.902039 cm /Im17 Do Q Q q 101.194 554.264 134.904 -138.768 re W n q 135.276001 0 0 138.786011 100.84201 415.482056 cm /Im18 Do Q Q q 371.001 554.264 -135.24 -138.768 re 235.762 554.264 m W n q 135.276001 0 0 138.786011 235.752014 415.482056 cm /Im19 Do Q Q q 370.666 554.264 134.865 -138.768 re W n q 135.276001 0 0 138.786011 370.662018 415.482056 cm /Im20 Do Q Q q 101.194 415.832 134.904 -138.6 re W n q 135.276001 0 0 138.636017 100.84201 277.212006 cm /Im21 Do Q Q q 371.001 415.832 -135.24 -138.6 re 235.762 415.832 m W n q 135.276001 0 0 138.636017 235.752014 277.212006 cm /Im22 Do Q Q q 370.666 415.832 134.865 -138.6 re W n q 135.276001 0 0 138.636017 370.662018 277.212006 cm /Im23 Do Q Q q 101.194 277.569 404.337 -46.148 re W n q 405.065979 0 0 46.56601 100.84201 231.011993 cm /Im24 Do Q Q q 89.745 699.76 415.786 -468.34 re W n BT /F24 1 Tf 9.8 0 0 9.8 89.8132 691.6262 Tm 0 0.003922 0 rg 0 Tc (A)Tj ET Q BT /F24 1 Tf 9.8 0 0 9.8 89.8125 452.9268 Tm 0 0.003922 0 rg 0 Tc (B)Tj ET EMC EMC BT /F1 1 Tf 6.9999 0 0 6.9999 50.6268 210.3307 Tm 0 0 0 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[(Frontiers)-306.1(in)-296.3(Cellular)-302.6(and)-306.5(Infection)-301.5(Microbiology)-499.5(|)-502.8(www.frontiersin.org)-24207.1(August)-303.6(2021)-505.2(|)-494.7(Volume)-307.7(11)-499.6(|)-494.7(Article)-305.6(679624)]TJ 35.7658 0 TD (7)Tj ET endstream endobj 133 0 obj<>stream HkPTIjl*8hQEAM0t"#^m:ǦLNPP rGK[(ZG+1޸Hr]4*# r˿gj pׇ};g"׎F\reMM`Bn05sLBVm,Maa9sΝ{ [?֖1o<KT__>KqȑٳgO6-$$$44T.M>7&&FѤ"^ڠחz_Bnj Bn0z͙z`^Vqq9JJJZ퀯|]@q6A[Wt4O;uJAFO\.^F&UU T_  %R|'s3O&M)1YR2e짦&VRF)6U\gujJI={XǺrrrdruu---ef#H8[@LCI|[5/hMoԤdq|}mQ)>=,_n7(w<*էSyԖ[\h|Ӥ&w2i'+:*ˍhnfv4 dc]nM4InnUVVbn88@VfAWiLi{t gSn~}4l-m;{{JHȳP{__d/󿜬+|5!^/eF1$Vt5>}Ur>`Tc=r+//>|800e 1yN/d_]kd['Z#Ƀ wn/*/8!,$@%ӭgr"/(\ %?6EWCFrBӹ[i^T3} c7`1zaϺ<ѨT*GܲNLE*D v2-zŴځBY}2ar䖅Φ0pnVųo[ \țC(~@ ʻƦvnدftۭƶ<^3=:zzzn݊ܲڙeN˓,^2u>ꨝU𴺹EG@vn2PMh@ @R{+ ._CꮭyٖUUo];=Bn[G.Ǐ:mQ4gqQpnzFH=MZ/~䙸  r~@Enm.3nifƝ#2:%̧Bn[Z}C>T<- ѹ6AD-&8=}@fb[- -  QvQd*]et*An1Bn[O:5?pi$;.A/ ay'e]An!-ɐ[|Cn!-mg>K ipZAe e2[%u.݁VQT...fzMr+!lOrrrI>s nɉ]rAe 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[(cant)-374.8(improvements)-387.7(in)-374.6(hypertension-)]TJ -10.6881 -1.2114 TD [(related)-255(risk)-259.6(factors)-256.1(\(including)-259.3(HOMA)]TJ /F13 1 Tf 15.0683 0 TD ()Tj /F12 1 Tf 0.5073 0 TD [(IR\))-255.6(after)-254.8(WMT,)-257.1(although)]TJ -15.5756 -1.2114 TD [(several)-219.2(studies)-219.9(have)-216.8(shown)-215.7(that)-218.3(FMT)-218.9(improves)-214.8(insulin)-224(sensitivity)]TJ T* (signi)Tj /F14 1 Tf 1.8858 0 TD ()Tj /F12 1 Tf 0.5311 0 TD [(cantly)-341.1(\()]TJ 0 0 0 0.7 k 3.0853 0 TD [(Vrieze)-343.2(et)-338.3(al.,)-339.1(2012)]TJ 0 0 0 1 k 7.3462 0 TD (;)Tj 0 0 0 0.7 k 0.555 0 TD [(Kootte)-339.6(et)-338.3(al.,)-339.1(2017)]TJ 0 0 0 1 k 7.4596 0 TD [(\).)-340.1(Our)-334.4(non-)]TJ -20.8629 -1.2114 TD (signi)Tj /F14 1 Tf 1.8858 0 TD ()Tj /F12 1 Tf 0.5311 0 TD [(cant)-303.2(results)-302.4(might)-298.6(have)-300.4(been)-305.2(due)-298.5(to)-302(the)-296.6(small)-303.9(sample)-304.2(size)]TJ -2.4169 -1.2114 TD [(in)-362.7(our)-358.6(study)-360.3(and)-363.9(the)-362.3(lack)-359.4(of)-360.8(insulin)-367.2(resistance)-363(in)-362.7(many)-359.9(of)-360.8(our)]TJ 0 -1.2055 TD [(hypertensive)-307(patients.)]TJ 1.2651 -1.2114 TD [(The)-324.8(safety)-333.9(of)-325(WMT)-331.8(for)-331(treating)-327.5(hypertension)-336.9(is)-324.9(crucial.)-335.6(We)]TJ -1.2651 -1.2114 TD [(showed)-268.3(that)-272(the)-266.8(prevalence)-277.6(of)-265.3(AEs)-272.8(after)-266.8(WMT)-272.2(was)-270.5(low)-267.8(\(3.07%\).)]TJ T* [(The)-474(main)-480.3(AEs)-475.7(were)-478.3(abdominal)-475.4(pain,)-476.7(bloating,)-478.6(diarrhea,)-481.2(and)]TJ T* [(dizziness.)-366.6(Serious)-366.4(AEs)-362.3(were)-358.9(not)-363.8(observed)-364.9(in)-362.7(the)-356.3(present)-365.2(study:)]TJ T* [(WMT)-302(may)-298.1(be)-301.4(safe)-306.2(and)-298.3(ef)]TJ /F14 1 Tf 10.2524 0 TD ()Tj /F12 1 Tf 0.5311 0 TD [(cacious)-303.6(treatment)-303.3(for)-301.1(hypertension.)]TJ -9.5184 -1.2055 TD [(Ou)23.7(r)-202.9(s)11.9(tu)16.4(d)12.7(y)-204.4(h)11.8(a)13.3(d)-202.1(f)0(o)21.2(u)0(r)-196.1(m)12.3(ai)22.7(n)-205(l)0(i)20.7(m)12.3(it)18.9(a)13.3(t)0(i)18.9(o)0(n)20.5(s)0(.)-193.8(F)12.7(ir)15.3(s)11.9(t)0(,)-190.2(g)0(i)19.8(v)0(e)20.6(n)-199(th)21.4(at)-192(th)21.4(is)-193.6(wa)21.9(s)-202.9(a)]TJ -1.2651 -1.2114 TD 0.0152 Tc [(retro)-4(s)3.2(pe)-4.4(cti)-5.3(v)1.8(e)-529.6(s)-2.7(tudy,)-530.7(f)1.9(e)-4.4(w)-525.2(fe)-4.4(cal)-528.5(s)-2.7(amples)-527.9(w)-6(e)1.5(re)-523.6(c)-4.4(o)2(lle)-4.4(c)1.5(t)-5.1(e)1.5(d)-527(f)-4.1(ro)-4(m)]TJ T* 0 Tc [(hy)-19.5(pe)-18.8(rt)-14.3(e)-13.7(n)-8(si)-20.5(v)-7.5(e)-526.9(p)-11.1(a)-10.6(t)-8.3(i)-8.5(e)-7.7(n)-8(t)-8.3(s)-12(,)-528(a)-10.6(n)-8(d)-530.3(t)-8.3(h)0(e)-533(f)-13.4(e)-7.7(c)-7.7(a)-10.6(l)-525.8(m)-11.5(e)-7.7(t)-8.3(a)-10.6(b)-7.3(o)-13.2(l)-6.6(i)-8.5(s)-12(m)-524.8(i)-8.5(n)-533.2(p)0(a)-15.7(t)-8.3(i)-8.5(e)-13.7(n)-8(t)-8.3(s)]TJ T* 0.0534 Tc [(before)-563(and)-560.5(a)-4.9(fter)-561.3(WMT)-567.9(w)2.3(ere)-563(n)-2.4(ot)-563.6(assessed.)-564.1(Hence,)-564.1(the)]TJ T* 0 Tc [(m)12.3(e)0(c)20.4(h)0(a)19.1(n)0(i)19.2(s)11.9(m)-363.6(u)0(n)16.7(d)0(e)17(r)11.9(ly)21.7(in)19.2(g)-365.5(t)15.6(he)-354(an)17.2(ti)18.9(h)11.8(y)0(p)23.2(e)0(r)16.1(t)0(e)19.8(n)0(s)21.8(i)0(v)19.8(e)-365.8(ef)86.4(fe)20.7(ct)-356.2(of)-354.8(W)13.2(M)0(T)-356.9(w)14.6(as)]TJ T* [(no)20.5(t)-247(e)0(l)21.5(u)0(c)17(i)0(d)22.1(a)0(t)16.9(e)0(d)22.9(.)-247.5(Se)18.7(co)20.8(nd)16.7(,)-247.5(t)15.6(hi)15.2(s)-244.7(w)0(a)21.9(s)-250.7(a)-243.3(s)0(i)15.3(n)0(g)20.3(l)0(e)21.5(-)13.8(ce)14.4(nt)25.4(er)-240.5(s)11.9(t)0(u)16.4(d)12.7(y)-246.2(w)0(i)18(t)0(h)-235.2(a)-249.3(s)11.9(m)0(a)19.7(l)0(l)]TJ T* [(s)11.9(a)0(m)19.7(p)0(l)18.1(e)-294.1(s)11.9(i)0(z)19.6(e)0(,)-285(s)11.9(o)-293.7(t)0(h)21.4(e)-294.1(s)11.9(t)0(a)16.9(t)15.6(is)15.3(t)15.6(i)0(c)19.6(a)0(l)-285.7(p)12.7(ow)19.3(er)-282.2(to)-284.1(d)12.8(e)0(t)19.8(e)0(c)20.4(t)-294.8(th)21.4(e)-294.2(e)0(f)80.4(f)0(e)20.7(c)0(t)19.8(s)-292.4(of)-283.2(W)13.2(M)0(T)]TJ 0 -1.2055 TD [(on)-277.9(h)11.8(y)0(p)17.2(e)0(r)22.1(t)0(e)19.8(n)0(s)15.8(i)15.3(on)20.5(-r)19.8(el)15.5(a)13.3(t)0(e)19.8(d)-291.6(r)11.9(i)0(s)21.3(k)-292.8(fa)23.8(ct)19.8(or)16.6(s)-286.5(m)12.3(ig)19.8(ht)-283(h)11.8(a)13.3(ve)-283.7(be)20.8(en)-278.3(in)19.2(s)11.9(u)0(f)]TJ /F14 1 Tf 23.0352 0 TD ()Tj /F12 1 Tf 0.5252 0 TD [(ci)19.6(en)20.1(t)15.6(.)]TJ -23.5603 -1.2114 TD [(Th)23.1(ir)15.3(d)12.7(,)-235.5(p)12.7(o)0(t)20.2(e)0(n)20.1(t)0(i)18.9(a)0(l)-226.1(c)0(o)20.8(n)0(f)20.4(o)0(u)23.4(n)0(d)16.7(e)0(r)22.1(s)-232.8(wh)20.4(ic)19.6(h)-232.9(m)0(i)15.7(g)0(h)22.2(t)-235.1(a)13.3(f)70.2(fe)20.7(ct)-224.9(bl)21.9(oo)21.3(d)-231.9(p)0(r)18.7(e)0(s)22.1(s)0(u)18.7(r)0(e)-222.6(i)0(n)]TJ T* [(th)21.4(e)-377.7(s)11.9(ho)16.5(r)11.9(t)-378.3(te)19.8(r)11.9(m)-381.5(\()14.8(e)0(.)19.3(g)0(.)19.6(,)-378.8(s)11.9(l)0(e)15.5(e)0(p)-365(q)0(u)21.5(a)0(l)18.6(i)0(t)18.9(y)0(,)-368.3(p)12.8(sy)16.4(ch)22(ol)21.9(og)21.1(ic)19.6(al)-369.3(s)11.9(t)0(a)16.9(t)15.6(e\))-368.9(we)18.8(r)11.9(e)-377.7(no)20.5(t)]TJ T* [(t)-8.3(a)0(k)-10.9(e)0(n)-523(i)-8.5(n)-8(t)0(o)-522.8(c)-7.7(o)-7.3(n)0(s)-8.1(i)-8.5(de)-12.9(ra)-10.6(t)-8.3(i)0(o)-9.8(n)0(.)-524(F)-11.1(ou)-12.4(rt)-8.4(h,)-528.1(th)-8.4(e)-526.9(s)0(u)-11.1(s)0(p)-11.1(e)-7.7(ns)-8.1(i)-8.5(o)0(n)-528.5(o)0(f)-527.9(w)0(a)-7.9(s)0(h)-12.1(e)-7.7(d)]TJ T* [(m)12.3(i)0(c)19.6(r)0(o)16.6(b)0(i)20(o)0(t)26.2(a)-338.8(wa)21.9(s)-340.2(n)0(o)20.5(t)-336.5(p)12.7(r)0(e)16.1(p)12.8(ar)19.2(ed)-329.1(u)12.8(n)0(d)16.7(e)0(r)-324(a)0(n)17.2(a)13.3(er)16.1(ob)21.3(ic)-326.6(co)20.8(nd)22.6(it)18.9(io)20(ns)21.8(.)-337(G)0(i)19.1(v)0(e)20.6(n)]TJ 27.4512 66.5811 TD [(th)21.4(at)-263.6(m)12.3(o)0(s)16.6(t)-270.9(of)-265.3(th)21.4(e)-270.3(b)0(e)20.9(n)0(e)]TJ /F14 1 Tf 8.4204 0 TD ()Tj /F12 1 Tf 0.5252 0 TD [(ci)19.6(a)13.3(l)-275.2(ba)23.9(ct)19.8(er)16.1(ia)-263.8(a)13.3(r)11.9(e)-276.2(s)11.9(tr)15.5(i)15.3(c)0(t)19.8(l)0(y)-264.7(a)0(n)17.2(a)13.3(er)22.1(ob)15.3(i)15.3(c)0(,)-267.1(s)11.9(om)17(e)-270.3(o)0(f)]TJ -8.9455 -1.2114 TD [(th)21.4(em)-466.8(m)12.3(i)0(g)19.8(h)11.8(t)-473.8(h)11.8(av)17.8(e)-473.2(d)0(i)16.1(e)0(d)-460.4(d)0(u)19.5(r)0(i)15.3(n)0(g)-463.1(t)0(h)21.4(i)0(s)-462.1(a)0(e)17.5(r)11.9(ob)21.3(ic)-463.8(pr)18.7(ep)17(a)13.3(r)0(a)19.2(t)0(i)18.9(o)0(n)20.5(,)-474.2(wh)20.4(ic)19.6(h)]TJ T* 0.0137 Tc [(introduced)-528.5(a)-522(b)0.5(ias)-523.4(f)0.3(avoring)-524.9(t)-0.6(he)-525.1(growth)-523.5(o)-5.5(f)-524.8(aerobic)-525.1(b)0.5(acteria.)]TJ T* 0 Tc [(Th)23.1(er)16.1(ef)20.7(or)22.6(e,)-386.5(ou)17.4(r)]TJ /F14 1 Tf 6.1944 0 TD ()Tj /F12 1 Tf 0.5192 0 TD [(nd)16.7(i)15.3(n)0(g)14.3(s)-393.9(on)-385.3(t)15.6(h)0(e)-389.8(a)13.3(nt)19.5(ih)21.2(yp)17.2(er)22.1(te)19.8(ns)21.8(iv)19.8(e)-395.6(e)0(f)80.4(f)0(e)20.7(c)0(t)-386(o)0(f)-384.6(W)13.2(MT)]TJ -6.7136 -1.2114 TD [(sho)-7.4(uld)-518.2(be)-516.2(inte)-8.7(rpret)-9.3(e)-7.7(d)-512.4(cauti)-10.5(ously)-8.6(,)-516(and)-519.1(l)-6.6(arge-s)-12(cale)-521.9(prosp)-11.7(ecti)-8.4(ve)]TJ T* [(s)11.9(t)0(u)16.4(d)12.8(ie)19.6(s)-292.4(a)13.3(re)-282.2(ne)20.1(ed)22.9(ed)-281.4(to)-278.1(ve)14.7(r)11.9(i)0(f)19.9(y)-288(ou)17.4(r)-286.5(c)0(o)20.8(n)0(c)20.1(l)0(u)18.1(s)11.9(io)20(ns)15.8(.)]TJ /F1 1 Tf 11.9999 0 0 11.9999 306.1417 611.6597 Tm (CONCLUSIONS)Tj /F12 1 Tf 9.5 0 0 9.5 306.1417 591.6471 Tm [(W)-10.7(M)0(T)-518.1(h)-12.1(ad)-523(a)-511.9(b)-7.3(l)-12.6(o)-7.3(o)-7.3(d)-512.4(p)-11.1(r)0(e)-13.7(s)0(s)-18(u)0(r)-17.1(e)-7.7(-l)-10.7(o)-13.2(w)0(e)-11(r)-12(i)-8.5(n)-8(g)-514.7(e)-7.7(f)58.3(f)-7.4(e)-13.7(c)-7.7(t)-515.6(i)0(n)-517.8(h)-12.1(y)-7.5(p)0(e)-12.9(r)-12(t)-8.3(e)-7.7(n)-8(s)0(i)-14.5(v)-7.5(e)]TJ T* [(patients,)-459.3(especially)-456(in)-458.2(patients)-456.5(who)-452.3(underwent)-459.3(WMT)]TJ /F15 1 Tf 22.7606 0 TD (via)Tj /F12 1 Tf 1.653 0 TD (the)Tj -24.4137 -1.2055 TD 0.0145 Tc [(lo)-4.7(wer)-516.7(g)-4.9(astroi)-6(nte)-5.1(s)2.5(t)-5.8(i)0(nal)-517.3(t)0.2(ract)]TJ 12.0845 0 TD 0.0165 Tc [(and)-513.8(p)-0.6(atients)-514.7(w)1.3(ho)-515.9(did)-513.8(n)2.5(ot)-511(take)]TJ -12.0845 -1.2114 TD 0.028 Tc [(antihypertensive)-528.7(drugs.)-523.8(Ther)]TJ 12.7409 0 TD 0.0273 Tc [(ef)-4(ore,)-530.5(modulati)-5.1(o)2.1(n)-529.8(o)2.1(f)-529.1(t)1.1(he)-529.4(gut)]TJ -12.7409 -1.2114 TD 0.5573 Tc 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[(Metabolic)-244.4(Syndrome)-237.2(is)-237.7(Driven)-233(by)-236.3(Baseline)-240.4(Intestinal)-237.6(Microbiota)-239.9(Composition.)]TJ /F15 1 Tf 0 -1.2699 TD [(Cell)-308.6(Metab.)]TJ /F12 1 Tf 4.8757 0 TD [(26,)-298(611)]TJ /F13 1 Tf 2.9103 0 TD ()Tj /F12 1 Tf 0.514 0 TD [(619.)-302.8(doi:)-301.1(10.1016/j.cmet.2017.09.008)]TJ -9.6304 -1.2699 TD [(Lew)-8.8(is)-11(-Mikh)-13.3(ae)-8.7(l,)-507.1(A.)-508.6(M.,)-515.9(Dav)-8.8(oodv)-10(a)-9(ndi,)-517.1(A.,)-509.8(and)-512.7(Jafa)-17.3(rneja)-17.8(d,)-509.3(S.)-508.3(\(202)-11.5(0\))-9.5(.)-507.7(E)0(f)59.3(fec)-10.9(t)-506.8(o)0(f)]TJ 1.3304 -1.2624 TD 0.0301 Tc [(L)-5.8(a)-1.6(cto)-6.6(b)1(aci)-4.7(llus)-535.7(P)-5.1(lantarum)-533.7(Co)-6.6(nt)-8.1(aini)-4.7(ng)-532.4(Pr)-6.5(obi)-4.7(oti)-4.7(c)0.1(s)-535.7(o)1(n)-532.5(B)-6.7(lood)-538.4(Pr)-6.5(es)-6.5(sure)-7.4(:)-530.5(A)]TJ 0 -1.2699 TD 0.0376 Tc [(Syst)7(ematic)-536.7(Rev)4.3(i)2.8(ew)-532.7(and)-530.9(M)0.4(eta)5.9(-)-1.5(An)4.1(aly)4.3(s)1(is.)]TJ /F15 1 Tf 17.9001 0 TD 0.0368 Tc [(Pharmacol.)-535.5(Res.)]TJ /F12 1 Tf 7.6272 0 TD 0.035 Tc [(153,)-540.7(1046)-7.6(63.)]TJ -25.5273 -1.2624 TD 0 Tc [(doi:)-308.6(10.1016/j.phrs.2020.104663)]TJ -1.3304 -1.2699 TD [(Li,)-381.9(H.)-375.1(B.,)-379.4(Yang,)-381.8(T.,)-378.7(Richards,)-380.6(E.)-376.5(M.,)-379.8(Pepine,)-385.4(C.)-380.8(J.,)-375.9(and)-376.7(Raizada,)-387.6(M.)-378.6(K.)-378.4(\(2020a\).)]TJ 1.3304 -1.2624 TD 0.0535 Tc [(M)-6.4(a)-0.8(ter)-5.8(n)-2.7(al)-558.2(Tr)-5.8(eatment)-559.2(W)1(ith)-556.9(C)-1.1(apto)-5.9(pril)-558.2(Pe)-6.7(rs)-5.8(is)-5.8(tentl)-6.4(y)-554.3(Alt)-7.3(e)0.8(rs)-557.6(Gut-)-8.2(Brain)]TJ 0 -1.2699 TD 0.0609 Tc [(Communicatio)-6(n)-562.2(and)-560.5(A)-0.5(tte)-6.9(nuate)-6.9(s)-557.8(Hype)-6.9(rtension)-562.2(of)-562.8(Male)-558.7(Of)60.9(fs)-6(pring.)]TJ /F15 1 Tf T* 0 Tc (Hypertension)Tj /F12 1 Tf 5.556 0 TD [(75,)-298(1315)]TJ /F13 1 Tf 3.3941 0 TD ()Tj /F12 1 Tf 0.5065 0 TD [(1324.)-300(doi:)-301.1(10.1161/HYPERTENSIONAHA.120.14736)]TJ 7.4999 0 0 7.4999 45.3543 246.6141 Tm [(Li,)-283.6(J.,)-285.2(Zhao,)-283.5(F.,)-291.3(Wang,)-280.7(Y.,)-284.5(Chen,)-283.7(J.,)-285.2(Tao,)-287.1(J.,)-285.2(Tian,)-288.4(G.,)-284.7(et)-279.8(al.)-289.3(\(2017\).)-279.2(Gut)-284.2(Microbiota)]TJ 1.3304 -1.2699 TD [(Dysbiosis)-245.1(Contributes)-241.3(to)-233.6(the)-240.1(Development)-241.3(of)-244.6(Hypertension.)]TJ /F15 1 Tf 24.0759 0 TD (Microbiome)Tj /F12 1 Tf 4.989 0 TD [(5,)-232.8(14.)]TJ -29.0649 -1.2624 TD [(doi:)-308.6(10.1186/s40168-016-0222-x)]TJ -1.3304 -1.2699 TD [(Li,)-502.8(N.,)-503.1(Zuo,)-512.3(B.,)-500.4(Huang,)-512.9(S.,)-502(Zeng,)-510.4(B.,)-500.4(Han,)-508.3(D.,)-505.6(Li,)-502.8(T.,)-507.2(et)-499(al.)-501(\(2)-9.5(020b\).)-503(Spatial)]TJ 1.3304 -1.2624 TD 0.0154 Tc [(Heter)-6.1(o)1.4(geneity)-516.8(o)-6.2(f)-510(B)-6.3(acteri)-4.3(al)-513.2(Colo)-6.2(ni)-4.3(zati)-4.3(on)-517(Acro)-6.2(ss)-512.6(D)-4(i)3.3(f)57(f)4(e)-7(r)1.4(ent)-514.1(G)-2.3(ut)-514.1(Segm)-4.1(ents)]TJ 0 -1.2699 TD 0.0134 Tc [(F)-3.3(o)-0.6(ll)13.4(o)-7.6(w)2.5(in)-5(g)-511.3(I)-1.3(nte)13.4(r)-7.9(-)-3(S)13.4(p)-11.5(ecie)13.4(s)-521.9(Microb)13.4(i)-5.2(o)-0.6(ta)-509.6(Tra)-3.2(n)2.6(spla)-3.1(ntation.)]TJ /F15 1 Tf 22.8513 0 TD 0.0178 Tc [(Mi)8.1(cro)17.8(b)-2.8(io)17.8(me)]TJ /F12 1 Tf 5.3897 0 TD 0.0123 Tc [(8,)-518.1(161.)]TJ -28.241 -1.2699 TD 0 Tc [(doi:)-308.6(10.1186/s40168-020-00917-7)]TJ -1.3304 -1.2624 TD [(Magoc,)-336.4(T.,)-333.3(and)-331.3(Salzberg,)-335.7(S.)-334.5(L.)-332(\(2011\).)-332.1(FLASH:)-331(Fast)-334.8(Length)-335.3(Adjustment)-335.5(of)-327.7(Short)]TJ 1.3304 -1.2699 TD 0.5507 Tc [(R)522.2(e)528.3(a)526.6(d)526.4(st)527.7(oI)528.4(m)523.6(p)526.4(r)529.2(o)521.6(v)524.9(e)6.7(G)525.5(e)528.3(n)524.8(o)521.6(m)531.2(e)-0.9(A)527.1(s)521.6(s)529.2(e)528.3(m)523.6(b)529.1(l)521(i)531(e)520.7(s)529.2(.)]TJ /F15 1 Tf 17.9832 0 TD 0.0239 Tc [(Bio)-7(i)-0.9(nformati)-8.5(c)5.8(s)]TJ /F12 1 Tf 6.6369 0 TD 0.0275 Tc [(27)7.6(,)-525.5(2)7.6(95)7.6(7)]TJ /F13 1 Tf 3.7871 0 TD 0 Tc ()Tj /F12 1 Tf 0.5367 0 TD 0.0199 Tc [(29)-7.6(63)-7.6(.)]TJ -28.944 -1.2624 TD 0 Tc [(doi:)-308.6(10.1093/bioinformatics/btr507)]TJ -1.3304 -1.2699 TD [(Marques,)-239.4(F.)-229.6(Z.,)-233.4(Mackay,)-235.4(C.)-229.6(R.,)-235(and)-233(Kaye,)-231.5(D.)-232.2(M.)-235(\(2018\).)-233.9(Beyond)-232.4(Gut)-231.3(Feelings:)-238.3(How)]TJ 1.3304 -1.2624 TD [(the)-391.3(Gut)-382.4(Microbiota)-391.1(Regulates)-388(Blood)-383.4(Pressure.)]TJ /F15 1 Tf 19.2532 0 TD [(Nat.)-384.4(Rev.)-387(Cardiol.)]TJ /F12 1 Tf 7.7103 0 TD [(15,)-388.7(20)]TJ /F13 1 Tf 2.5248 0 TD ()Tj /F12 1 Tf 0.5065 0 TD (32.)Tj -29.9947 -1.2699 TD [(doi:)-308.6(10.1038/nrcardio.2017.120)]TJ -1.3304 -1.2699 TD [(Marques,)-247(F.)-252.2(Z.,)-248.5(Nelson,)-245.1(E.,)-249.2(Chu,)-244.5(P.)-248(Y.,)-246.7(Horlock,)-252.3(D.,)-241(Fiedler,)-256.2(A.,)-245.2(Ziemann,)-248.8(M.,)-251.3(et)-242(al.)]TJ 1.3304 -1.2624 TD 0.0168 Tc [(\(2017\).)-521.1(H)-1.8(igh-Fiber)-518.7(D)-2.6(iet)-520.3(a)0.3(nd)-513.9(Ac)-5.6(etate)-519.7(S)1(u)-7.5(pple)-5.6(m)4.9(e)-5.6(n)6(t)-6.2(a)0.2(tion)-515.6(Change)-512.1(t)-6.2(h)3.5(e)-519.7(G)-0.9(ut)]TJ 0 -1.2699 TD 0 Tc [(Microbiota)-315.5(and)-308.6(Prevent)-312.3(the)-308.2(Development)-316.9(of)-305.1(Hypertension)-318(and)-308.6(Heart)-313.8(Failure)]TJ 0 -1.2624 TD 0.0812 Tc [(in)-579.7(Hype)5.9(rt)5.2(ensive)-576.2(M)6.2(i)1(ce)5.9(.)]TJ /F15 1 Tf 11.5201 0 TD 0.0838 Tc [(Ci)6.1(rc)5.2(u)10.1(l)-2.2(a)5.9(t)7.8(i)6.1(o)0(n)]TJ /F12 1 Tf 5.9188 0 TD 0.0804 Tc [(135,)-578.5(964)]TJ /F13 1 Tf 4.2256 0 TD 0 Tc ()Tj /F12 1 Tf 0.5896 0 TD 0.0805 Tc [(977.)-578.4(doi:)-578.4(10)7.7(.116)7.7(1/)]TJ -22.2541 -1.2699 TD 0 Tc (CIRCULATIONAHA.116.024545)Tj 33.4417 83.5815 TD [(Matthews,)-259.8(D.)-262.5(R.,)-257.7(Hosker,)-260.3(J.)-261.3(P.,)-256.8(Rudenski,)-268.4(A.)-259.1(S.,)-260.1(Naylor,)-261.7(B.)-257.3(A.,)-260.3(Treacher,)-260.5(D.)-262.5(F.,)-261(and)]TJ 1.3304 -1.2699 TD [(Turner,)-304.1(R.)-294.3(C.)-290.1(\(1985\).)-294.3(Homeostasis)-303.1(Model)-293.9(Assessment:)-299.7(Insulin)-297.8(Resistance)-299.6(and)]TJ 0 -1.2624 TD [(Beta-Cell)-297(Function)-292.9(From)-290.9(Fasting)-292.8(Plasma)-290.1(Glucose)-295.6(and)-293.5(Insulin)-290.2(Concentrations)]TJ 0 -1.2699 TD [(in)-302.6(Man.)]TJ /F15 1 Tf 3.4848 0 TD (Diabetologia)Tj /F12 1 Tf 5.2914 0 TD [(28,)-305.6(412)]TJ /F13 1 Tf 2.9178 0 TD ()Tj /F12 1 Tf 0.5065 0 TD [(419.)-302.8(doi:)-301.1(10.1007/BF00280883)]TJ -13.5309 -1.2624 TD [(Mills,)-501.8(K.)-506.9(T.,)-499.6(St)-8.6(efanescu,)-508.3(A.,)-502.2(and)-505.2(He,)-503.3(J.)-503.2(\(2020\).)-506(The)-502.6(Globa)-8.8(l)-498.4(Epidemiology)-508.6(of)]TJ 1.3304 -1.2699 TD [(H)-11(y)-10.7(p)-9.1(e)0(r)-21.3(t)-7.9(en)-18.1(s)-14(i)0(o)-18.6(n)-10.8(.)]TJ /F15 1 Tf 6.2968 0 TD 0.0128 Tc [(Nat)4.9(.)-506.6(Re)12.8(v.)-506.6(Ne)12.8(phr)12.8(o)-1.8(l.)]TJ /F12 1 Tf 8.436 0 TD 0.0123 Tc [(16)12.3(,)-515.3(2)0(2)12.3(3)]TJ /F13 1 Tf 3.1824 0 TD 0 Tc ()Tj /F12 1 Tf 0.5216 0 TD [(23)-17.1(7.)-527.6(d)-9.1(o)0(i)-18.6(:)-522.8(10)-17.1(.)-8.8(1)-12.4(03)-17.1(8)-12.3(/)0(s)-17(4)-12.3(15)-17.1(81)-17.1(-)-8.8(0)-12.4(19)-17.1(-)]TJ -18.4368 -1.2699 TD (0244-2)Tj -1.3304 -1.2624 TD [(Mullish,)-229.4(B.)-219.5(H.,)-225.1(Quraishi,)-230.2(M.)-227.4(N.,)-223.4(Segal,)-232.4(J.)-223.5(P.,)-226.6(Mccune,)-223.9(V.)-226.4(L.,)-227.3(Baxter,)-228.1(M.,)-228.6(Marsden,)-223.5(G.)]TJ 1.3304 -1.2699 TD [(L.,)-371(et)-378.1(al.)-364.9(\(2018\).)-377.5(The)-366.6(Use)-373.2(of)-373.1(Faecal)-373.8(Microbiota)-368.5(Transplant)-377.1(as)-370.7(Treatment)-376.8(for)]TJ 0 -1.2624 TD [(Recurrent)-416.1(or)-405.9(Refractory)-403.7(Clostridium)-415.3(Dif)]TJ /F14 1 Tf 16.6453 0 TD ()Tj /F12 1 Tf 0.5291 0 TD [(cile)-411.7(Infection)-406.3(and)-406.9(Other)-407.1(Potential)]TJ -17.1744 -1.2699 TD [(Indications:)-395.3(Joint)-388.1(British)-389.9(Society)-392.6(of)-388.2(Gastroenterology)-391.8(\(BSG\))-389.7(and)-391.8(Healthcare)]TJ 0 -1.2624 TD [(Infection)-406.3(Society)-392.6(\(HIS\))-406.2(Guidelines.)]TJ /F15 1 Tf 14.7479 0 TD (Gut)Tj /F12 1 Tf 1.9049 0 TD [(67,)-396.3(1920)]TJ /F13 1 Tf 3.4848 0 TD ()Tj /F12 1 Tf 0.514 0 TD [(1941.)-398.3(doi:)-399.3(10.1136/gutjnl-)]TJ -20.6516 -1.2699 TD (2018-316818)Tj -1.3304 -1.2699 TD [(Mushtaq,)-443.4(N.,)-450.2(Hussain,)-444(S.,)-449.1(Zhang,)-442.2(S.,)-449.1(Yuan,)-440.7(L.,)-446.6(Li,)-442.3(H.,)-451.9(Ullah,)-442.3(S.,)-441.5(et)-446.1(al.)-448.1(\(2019\).)]TJ 1.3304 -1.2624 TD [(Mol)-12.9(ecul)-15.6(ar)-514.3(Cha)-8.8(ract)-15.5(eri)-10.7(za)-8.7(tio)-11.4(n)-502.2(o)0(f)-516.7(Alt)-8.2(era)-15.1(tion)-14.6(s)-505.3(i)0(n)-506.7(t)-7.9(he)-511.9(Int)-10.8(esti)-11.1(na)-12.2(l)-505.9(Mic)-11.3(rob)-11.7(iot)-11.4(a)-500.3(o)0(f)]TJ 0 -1.2699 TD 0.0292 Tc [(Patie)6.8(n)-4.3(t)6.2(s)-529(With)-520.8(Grade)-522.4(3)-527.4(Hypert)6.2(ension.)]TJ /F15 1 Tf 17.3407 0 TD 0.0261 Tc [(I)-3.7(n)-2.3(t.)-531.1(J.)-531(Mo)-4.8(l.)-531.1(Med.)]TJ /F12 1 Tf 8.247 0 TD 0.0275 Tc [(44,)-525.5(5)-7.5(1)0(3)]TJ /F13 1 Tf 3.3109 0 TD 0 Tc ()Tj /F12 1 Tf 0.5367 0 TD 0.0275 Tc (522.)Tj -29.4353 -1.2624 TD 0 Tc [(doi:)-301.1(10.3892/ijmm.2019.4235)]TJ -1.3304 -1.2699 TD 0.0224 Tc [(O)5.5(p)-1.9(aril)7.8(,)-523.1(S)-0.9(.)6.1(,)-523.1(A)6.4(cela)5.9(j)0.3(ad)5.7(o,)-515.5(M.)-523.1(C)5.6(.)-1.5(,)-515.5(B)0.7(ak)4.9(ris,)-523.1(G)4.7(.)-523.1(L.)6.1(,)-523.1(B)8.2(erlow)4(i)2.7(tz,)-515.5(D)3(.)-523.1(R)1.4(.)6.1(,)-523.1(C)5.6(i)2.7(fk)4.9(ov)4.2(a,)-515.5(R.,)]TJ 1.3304 -1.2624 TD 0 Tc [(Dominiczak,)-500.6(A.)-501(F.,)-495.4(et)-491.5(al.)-501(\(2018\).)-498.4(Hypertension.)]TJ /F15 1 Tf 20.5307 0 TD [(Nat.)-490.2(Rev.)-500.3(Dis.)-496.8(Primers)]TJ /F12 1 Tf 9.9478 0 TD (4,)Tj -30.4785 -1.2699 TD [(18014.)-304.8(doi:)-301.1(10.1038/nrdp.2018.14)]TJ -1.3304 -1.2699 TD [(Robles-Vera,)-267.2(I.,)-259(Toral,)-262.7(M.,)-266.4(de)-258.3(la)-265.4(Visitacion,)-265.3(N.,)-261.2(Sanchez,)-268.5(M.,)-258.8(Gomez-Guzman,)-270.2(M.,)]TJ 1.3304 -1.2624 TD 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endobj 363 0 obj<> endobj 364 0 obj<> endobj 365 0 obj<> endobj 366 0 obj<> endobj 367 0 obj<> endobj 368 0 obj<> endobj 369 0 obj<> endobj 370 0 obj<> endobj 371 0 obj<> endobj 372 0 obj<> endobj 373 0 obj<> endobj 374 0 obj<> endobj 375 0 obj<> endobj 376 0 obj<> endobj 377 0 obj<> endobj 378 0 obj<> endobj 379 0 obj<> endobj 380 0 obj<> endobj 381 0 obj<> endobj 382 0 obj<> endobj 383 0 obj<> endobj 384 0 obj<> endobj 385 0 obj<> endobj 386 0 obj<> endobj 387 0 obj<> endobj 388 0 obj<> endobj 389 0 obj<> endobj 390 0 obj<>/Type/Filespec>> endobj 391 0 obj<>stream Acrobat Distiller 7.0 (Windows) washed microbiota transplantation, hypertension, treatment, gut microbiota, blood pressure 2021-08-06T13:16:50+08:00 2021-08-06T13:16:50+08:00 Arbortext Advanced Print Publisher 10.0.1306/W Unicode application/pdf Washed Microbiota Transplantation Lowers Blood Pressure in Patients With Hypertension Hao-Jie Zhong; Hong-Lie Zeng; Ying-Li Cai; Yu-Pei Zhuang; Yu-Ligh Liou; Qingping Wu; Xing-Xiang 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629 0 obj<> endobj 655 0 obj<> endobj 656 0 obj<>stream Acrobat Distiller 7.0 (Windows) washed microbiota transplantation, hypertension, treatment, gut microbiota, blood pressure 2021-08-06T13:36:11-08:00 2021-08-06T13:16:50+08:00 Arbortext Advanced Print Publisher 10.0.1306/W Unicode 2021-08-06T13:36:11-08:00 application/pdf Washed Microbiota Transplantation Lowers Blood Pressure in Patients With Hypertension Hao-Jie Zhong Hong-Lie Zeng Ying-Li Cai Yu-Pei Zhuang Yu-Ligh Liou Qingping Wu Xing-Xiang He Background: Although transplantation of the fecal microbiota from normotensive donors has been shown to have an antihypertensive effect in hypertensive animal models, its effect on blood pressure in patients with hypertension is unclear. washed microbiota transplantation hypertension treatment gut microbiota blood pressure uuid:da082044-2284-4b13-8d58-55974e1e0023 uuid:6a6d996d-ccac-4754-a9b2-5d1d7031ed60 endstream endobj xref 385 3 0001553250 00000 n 0001553313 00000 n 0001553449 00000 n 392 1 0001553518 00000 n 394 1 0001554266 00000 n 628 2 0001554439 00000 n 0001554496 00000 n 655 2 0001554789 00000 n 0001555452 00000 n trailer <]/Prev 116 >> startxref 1560358 %%EOF